Occupational Hydrocarbon Exposure and Renal Histopathology
Occupational Hydrocarbon Exposure and Renal Histopathology
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职业碳氢化合物暴露和肾脏组织病理学
DOI：
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发表时间：
1987
影响因子：
1.9
通讯作者：
Fred G. Silva
中科院分区：
文献类型：
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作者：
J. Piťha;G. Hemstreet;N. Asal;R. Petrone;B. Trump;Fred G. Silva
对 10 例暴露于碳氢化合物和 20 例未暴露的肾细胞癌病例的组织学切片进行了盲法回顾性研究，以评估随肿瘤切除的明显正常肾实质中存在的组织病理学特征。三十个病例中每个病例的组织切片均由三名咨询病理学家独立审查，并使用明确的标准进行评分。职业碳氢化合物暴露指数由工业卫生学家团队制定，并应用于每个暴露病例的详细职业史。年龄与总肾脏病理评分之间观察到正相关（rs = .40，p < .03）。在暴露病例中，未发现职业性碳氢化合物暴露指数与肾脏病理评分之间存在相关性。当暴露病例与未暴露病例按年龄、性别和种族进行匹配时，肾脏病理评分没有显着差异。这些结果受到仅包含历史碳氢化合物暴露案例的限制。建议利用敏感的定量方法进行后续研究，以确定与当前职业接触碳氢化合物相关的细胞病理学肾效应（如果有）。
A blinded, retrospective study of histological sections from ten hydrocarbon-exposed and twenty unexposed nephrectomized renal cell carcinoma cases was conducted to evaluate the histopathologic features present in the apparently normal kidney parenchyma removed with the tumor. Tissue sections from each of the thirty cases were independently reviewed by three consulting pathologists and scored using well defined criteria. Occupational hydrocarbon exposure indices were developed by a team of industrial hygienists and applied to the detailed occupational history of each exposed case. A positive correlation was observed between age and the total renal pathology score (r s = .40, p < .03). No correlation was found between indices of occupational hydrocarbon exposure and renal pathology scores among exposed cases. No significant differences in renal pathology scores were noted when exposed cases were matched to unexposed cases by age, sex, and race. These results are limited by the inclusion of only cases with historical hydrocarbon exposures. It is recommended that a follow-up study be conducted, utilizing sensitive quantitative methods, to define what, if any, cytopathologic renal effects occur in conjunction with current occupational exposures to hydrocarbons.