Regulatory T cells in type 1 autoimmune pancreatitis.
Regulatory T cells in type 1 autoimmune pancreatitis.
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DOI：
10.1155/2012/795026
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发表时间：
2012
影响因子：
2.3
通讯作者：
Okazaki K
中科院分区：
文献类型：
--
作者：
Uchida K;Kusuda T;Koyabu M;Miyoshi H;Fukata N;Sumimoto K;Fukui Y;Sakaguchi Y;Ikeura T;Shimatani M;Fukui T;Matsushita M;Takaoka M;Nishio A;Okazaki K
自身免疫性胰腺炎（AIP）是一种新近发现的胰腺疾病。国际公认的AIP诊断标准（International Consensus Diagnosis Criteria for AIP，ICDC）在本ICDC中，AIP被分为1型和2型。1型AIP患者有几种特定于该疾病的免疫学和组织学异常，包括血清IgG 4水平升高和Storiform纤维化伴淋巴细胞和IgG 4阳性浆细胞浸润。在胰外病变累及的器官中，胆管最常见，表现为硬化性胆管炎（IgG 4-SC）。然而，IgG 4的作用尚不清楚。最近，据报道，调节性T细胞（Tcells，Tcells）参与各种自身免疫性疾病的发展和B细胞向IgG 4的转变，产生浆细胞。我们的研究表明，与对照组相比，1型AIP和IgG 4-SC组胰腺中的TcR增加。在1型AIP和IgG 4-SC患者中，浸润的T细胞数量与IgG 4阳性浆细胞呈显著正相关。在1型AIP中，与对照组相比，诱导型共刺激分子（ICOS）+和IL-10+ T细胞显著增加。我们的数据表明，增加ICOS+ TIFE的数量可能会影响IgG 4的生产，通过IL-10在1型AIP。
Autoimmune pancreatitis (AIP) is a newly recognized pancreatic disorder. Recently, International Consensus Diagnostic Criteria for AIP (ICDC) was published. In this ICDC, AIP was classified into Type 1 and Type 2. Patients with Type 1 AIP have several immunologic and histologic abnormalities specific to the disease, including increased levels of serum IgG4 and storiform fibrosis with infiltration of lymphocytes and IgG4-positive plasmacytes in the involved organs. Among the involved organs showing extrapancreatic lesions, the bile duct is the most common, exhibiting sclerosing cholangitis (IgG4-SC). However, the role of IgG4 is unclear. Recently, it has been reported that regulatory T cells (Tregs) are involved in both the development of various autoimmune diseases and the shift of B cells toward IgG4, producing plasmacytes. Our study showed that Tregs were increased in the pancreas with Type 1 AIP and IgG4-SC compared with control. In the patients with Type 1 AIP and IgG4-SC, the numbers of infiltrated Tregs were significantly positively correlated with IgG4-positive plasma cells. In Type 1 AIP, inducible costimulatory molecule (ICOS)+ and IL-10+ Tregs significantly increased compared with control groups. Our data suggest that increased quantities of ICOS+ Tregs may influence IgG4 production via IL-10 in Type 1 AIP.