DnaK chaperone machine and trigger factor are only partially required for normal growth of Bacillus subtilis
DnaK chaperone machine and trigger factor are only partially required for normal growth of Bacillus subtilis
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DOI：
10.1271/bbb.66.1583
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发表时间：
2002-07-01
影响因子：
1.6
通讯作者：
Yoshikawa, H
中科院分区：
文献类型：
--
作者：
Reyes, DY;Yoshikawa, H
虽然dNAK和tig是大肠杆菌中新生多肽折叠的必要成分，但缺失并不会导致枯草杆菌的合成致死，这表明在正常生长条件下，另一种具有特定作用的系统或机制占优势。同样，由于几组热休克基因的缺失，在高温下的生存也受到了极大的影响，因此在突然应激期间，各种热休克基因协同作用来保护蛋白质。
While dnaK and tig are the essential components for nascent polypeptide folding in E. coli, deletion did not confer synthetic lethality in B. subtilis, suggesting that under normal growth conditions, another system or mechanism with a specific role prevails. Likewise, survival at high temperature suffered dramatically, resulting from deletion of several sets of heat shock genes, thus during sudden stress various heat shock genes act synergistically to protect the proteins.