MEASURING THE SUBJECTIVE MAGNITUDE OF BRAIN-STIMULATION REWARD BY TITRATION WITH RATE OF REWARD
MEASURING THE SUBJECTIVE MAGNITUDE OF BRAIN-STIMULATION REWARD BY TITRATION WITH RATE OF REWARD
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DOI：
10.1037/0735-7044.105.6.913
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发表时间：
1991-12-01
影响因子：
1.9
通讯作者：
LEON, M
中科院分区：
文献类型：
--
作者：
GALLISTEL, CR;LEON, M
实验采用一种新的心理物理方法，通过调整一个脑刺激刺激的参数来抵消另一个脑刺激刺激的频率变化的影响，从而测量大鼠前脑内侧束的脉冲频率和电流在固定时间内的变化。主观奖励幅度是脉冲频率和电流的陡s型函数。奖励增长到半大水平可以用指数在2到10之间变化的幂函数来表示。在一个实验对象中，电流和脉冲频率的指数是相同的，这支持了一个假设，即从固定持续时间的训练中获得的奖励的大小是由与奖励相关的轴突群体中产生动作电位的速率决定的（反假设）。该速率与电流x脉冲频率成正比。
The magnitude of experienced reward as a function of the pulse frequency and current in trains of fixed duration delivered to the medial forebrain bundle of the rat was measured using a new psychophysical method in which the parameters of the brain stimulation reward on one lever are adjusted to offset the effect of changing the rate of reward on a competing lever. Subjective reward magnitude is a steep sigmoidal function of both pulse frequency and current. The growth of reward to its half-maximal level was approximated by a power function with an exponent that varied from 2 to 10. Within a subject, the exponent was the same for both current and pulse frequency, which supports the hypothesis that the magnitude of reward from a train of fixed duration is determined by the rate at which action potentials are generated in the population of reward-relevant axons (the counter hypothesis). This rate is proportional to Current x Pulse Frequency.