Relation of adult height with stroke mortality in Japan NIPPON DATA80
Relation of adult height with stroke mortality in Japan NIPPON DATA80
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DOI：
10.1161/01.str.0000251806.01676.60
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发表时间：
2007-01-01
期刊：
影响因子：
8.3
通讯作者：
Ueshima, Hirotsugu
中科院分区：
文献类型：
--
作者：
Hozawa, Atsushi;Murakami, Yoshitaka;Ueshima, Hirotsugu
背景和目的--日本的年龄校正卒中死亡率在1950 - 1970年代是世界上最高的，但在1965年后开始急剧下降。除了改善对高血压的管理外，平均身高的增加也可能有助于这种降低。本研究调查身高是否是中风死亡率的独立危险因素，在日本，1980年从日本人口中随机选择的全国心血管疾病调查的参与者中，我们对3969名和4955名既往无心血管疾病的日本男性和女性进行了最长19年的随访，观察到158名和132名中风死亡。身高与年龄和粗卒中死亡率呈负相关。当我们校正年龄或其他可能的混杂因素时，男性中的相关性减弱（身高增加5 cm对卒中死亡率的多变量校正相对危险度：0.92，95%CI：0.79至1.08）。对于女性，在多变量调整后仍保持反比关系（相对风险：0.77：95%CI：0.64至0.91）。这些关系持续存在时，我们分层参与者的年龄。结论高度与中风死亡率呈负相关，这种关系在日本妇女中具有统计学意义。
Background and Purpose-The age-adjusted stroke mortality rate in Japan was the highest in the world from 1950 to the 1970s, but it started to dramatically decrease after 1965. In addition to improved management of high blood pressure, the increase in average height might also contribute to this reduction. The present study investigates whether height is an independent risk for stroke mortality in Japan.Methods-Among participants of the National Survey on Cardiovascular Diseases in 1980 who were randomly selected from the Japanese population, we followed up 3969 and 4955 Japanese men and women without prior cardiovascular disease for a maximum of 19 years and observed 158 and 132 stroke deaths.Results-Height was inversely correlated with age and with crude stroke mortality. The relationship was attenuated in men when we adjusted for age or other possible confounders (multivariate adjusted relative hazards of a 5-cm increase of height for stroke mortality: 0.92, 95% CI: 0.79 to 1.08). For women, the inverse relationship (relative hazard: 0.77: 95% CI: 0.64 to 0.91) remained after multivariate adjustment. These relationships persisted when we stratified participants by age.Conclusions-Height is inversely related to stroke mortality and the relationship is statistically significant among Japanese women.