A study on histological grading of oral squamous cell carcinoma and its co-relationship with regional metastasis.
A study on histological grading of oral squamous cell carcinoma and its co-relationship with regional metastasis.
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DOI：
10.4103/0973-029x.84485
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发表时间：
2011-05
期刊：
影响因子：
--
通讯作者：
Molla MR
中科院分区：
文献类型：
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作者：
Akhter M;Hossain S;Rahman QB;Molla MR
组织学分级是预测肿瘤临床和生物学行为的重要诊断工具。颈部淋巴结转移提示口腔癌预后不良。考虑到一个第三世界国家的经济状况，Anneroth的分级系统比TNM分期和Broder分级系统更便宜，信息更丰富。Anneroth分级系统也显示与淋巴结转移相关。因此，我们试图将Anneroth的评分作为这三个系统中的一个标准。根据Anneroth对活检标本的分类与颈部淋巴结转移的关系，研究组织学恶性肿瘤的分级，并将Anneroth与其他两种公认的分类进行比较。50例口腔鳞状细胞癌患者被纳入研究。35例非转移性肿瘤标本与15例转移性肿瘤标本进行比较。所有患者均被分为TNM、Broder和Anneroth评分系统。TNM是临床评估，而Broder’s仅基于细胞分化。另一方面，Anneroth的6个参数详细说明了肿瘤的形态、在宿主组织中的侵袭标准以及与淋巴结转移的相关性。Annearoth分级评分系统是肿瘤恶化的分界点，标志着淋巴结转移的可能性。Anneroth的评分（P=0.002）和Broder的评分（P=0.012）均显著，但Anneroth的评分比Broder的评分更显著。aneroth的分型可作为淋巴结转移的标准诊断因素和预测因素。
Histological grading is an important diagnostic tool to predict the clinical and biological behaviour of cancer. Cervical lymph node metastasis indicate poor prognosis of oral cancer. Considering economical status of a third world country, Anneroth's grading system is less expensive, more informative than TNM staging and Broder's grading system. Anneroth's grading system also shows co-relationship with lymph node metastasis. So we are trying to evaluate the Anneroth's grading as a standard one among these three system. To study the grading of histological malignancy according to Anneroth's classification of biopsy specimens in relation to metastasis in the cervical lymph nodes and comparing the Anneroth's with the other two recognized classifications. Fifty(50) patients with oral squamous cell carcinoma was included in the study. Specimen of 35 non-metastatic tumors were compared with 15 metastatic cases. All of the patients were graded to TNM, Broder's and Anneroth's system. TNM is clinical assessment and Broder's is based on only differentiation of cells. On the other hand, six parameters of Anneroth's gives a detail about the morphology of the tumor, invasion criteria in the host tissue and show its correlation with lymph node metastasis. Scoring system of Annearoth's grading indicates demarcation points of worseness of tumor and signifies the possibility of lymph node metastasis. Both Anneroth's(P=0.002) and Broder's grading(P=0.012) have been significant but Anneroth's one is more significant then Broder's. Anneroth's classification can be taken as a standerd diagnostic factor and predictive factor of lymph node metastasis.