Physicochemical stability of NOX-E36, a 40mer L-RNA (Spiegelmer) for therapeutic applications.
Physicochemical stability of NOX-E36, a 40mer L-RNA (Spiegelmer) for therapeutic applications.
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DOI：
10.1093/nass/nrn031
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发表时间：
2008-01-01
期刊：
影响因子：
--
通讯作者：
Klussmann, Sven
中科院分区：
文献类型：
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作者：
Maasch, Christian;Buchner, Klaus;Klussmann, Sven
Spiegelmers are structured mirror-image oligonucleotides that are designed to bind and inhibit pharmacologically relevant target molecules. The synthesis and purification of mirror-image oligonucleotides is comparable to the manufacturing of standard oligonucleotides that consist of naturally configured nucleotides. Due to the use of the non-natural L-nucleotides in Spiegelmers, these oligonucleotides show an exceptional biostability. Further, they also display a high physicochemical stability in solution. These properties make them interesting substances for drug development.
