HLA-DRB1 TYPING OF VOGT-KOYANAGI-HARADA DISEASE BY PCR-RFLP AND THE STRONG ASSOCIATION WITH DRB1-STAR-0405 AND DRB1-STAR-0410
HLA-DRB1 TYPING OF VOGT-KOYANAGI-HARADA DISEASE BY PCR-RFLP AND THE STRONG ASSOCIATION WITH DRB1-STAR-0405 AND DRB1-STAR-0410
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DOI：
10.1136/bjo.78.3.223
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发表时间：
1994-03-01
影响因子：
4.1
通讯作者：
OHNO, S
中科院分区：
文献类型：
--
作者：
SHINDO, Y;INOKO, H;OHNO, S
Vogt-Koyanagi-Harada's (VKH) disease is reported to be closely associated with the HLA class II antigen, HLA-DR4. Serologically defined DR4 is further divided into 11 alleles by molecular HLA genotyping. However, no study of HLA-DNA typing of VKH patients has been reported. To clarify molecular genetic mechanism underlying the susceptibility/resistance to VKH disease, HLA-DNA typing of DR antigens (DRB1 genotyping) by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method was performed. It was found that DRB1*0405 showed a significant association with VKH disease compared with the healthy controls (corrected p value
