Primary meningococcal pericarditis: a disease of adults associated with serogroup C Neisseria meningitidis.
Primary meningococcal pericarditis: a disease of adults associated with serogroup C Neisseria meningitidis.
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原发性脑膜炎球菌性心包炎：一种与 C 群脑膜炎奈瑟菌相关的成人疾病。
DOI：
10.1093/clinids/6.5.625
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
A. Hightower
中科院分区：
文献类型：
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作者：
M. Blaser;A. Reingold;R. N. Alsever;A. Hightower
脑膜炎奈瑟菌引起的心包炎通常是脑膜疾病或脑膜炎球菌血症的结果。本报告包括原发性脑膜炎球菌性心包炎（PMP）的病例报告和15个以前报告的病例的临床和流行病学特征的审查。所有病例都是在过去15年中报告的。大多数患者是年龄较大的青少年或成人。美国PMP病例的中位年龄和年龄分布明显大于疾病控制中心（CDC）报告的其他脑膜炎球菌疾病患者（P = 0.005）。血清群C N. 88%的美国PMP患者分离出脑膜炎球菌，相比之下，CDC报告的其他脑膜炎球菌疾病患者的分离率为22%（P = 0.00016）。心包液培养通常产生脑膜炎双球菌，大多数患者出现化脓性心包炎的典型体征和症状。心包培养阳性与心包填塞的发生相关（P = 0.03）。在适当的抗生素治疗和心包液引流（如有指征）下，所有16例患者均存活，后遗症很少或没有后遗症。
Pericarditis due to Neisseria meningitidis is usually a consequence of meningeal disease or meningococcemia. This presentation includes a case report of primary meningococcal pericarditis (PMP) and a review of the clinical and epidemiologic features of 15 previously reported cases. All cases have been reported in the past 15 years. Most patients were older teenagers or adults. The median age and age distribution of PMP cases in the United States were significantly greater than that of patients with other meningococcal diseases reported to the Centers for Disease Control (CDC) (P = .005). Similarly, serogroup C N. meningitidis was isolated from 88% of U.S. patients with PMP, compared with isolation from 22% of patients with other meningococcal diseases reported to the CDC (P = .00016). Culture of pericardial fluid usually yielded meningococci, and most patients presented with signs and symptoms typical of purulent pericarditis. A positive pericardial culture was associated with the development of cardiac tamponade (P = .03). With appropriate antibiotic treatment and drainage of pericardial fluid when indicated, all 16 patients survived and experienced few or no sequelae.