Association of Blood Donor Age and Sex With Recipient Survival After Red Blood Cell Transfusion
Association of Blood Donor Age and Sex With Recipient Survival After Red Blood Cell Transfusion
复制标题
DOI：
10.1001/jamainternmed.2016.3324
复制
发表时间：
2016-09-01
影响因子：
39
通讯作者：
Fergusson, Dean A.
中科院分区：
文献类型：
--
作者：
Chasse, Michael;Tinmouth, Alan;Fergusson, Dean A.
虽然红细胞（RBC）用于改善氧气输送和患者预后，但它们也与潜在的危害有关。与实体器官移植不同，供体特征对受者的临床后果尚未在输血医学中进行评估。目的分析红细胞供体年龄和性别与输血受者存活率的关系。与参与者我们通过将来自采血机构的数据与4家学术医院的临床和管理数据联系起来建立了一个纵向队列。主要结果和指标考克斯结果2006年10月25日至2013年12月31日，共有30 503例红细胞输注受者接受了来自80 755名独立献血者的187 960次红细胞输注。对于接受来自年轻供体的红细胞单位的受者，与接受来自40 - 49.9岁供体的红细胞单位的受者相比，死亡风险增加（调整后的风险比，1.08; 95%CI，1.06-1.10; P
IMPORTANCE While red blood cells (RBCs) are administered to improve oxygen delivery and patient outcomes, they also have been associated with potential harm. Unlike solid organ transplantation, the clinical consequences of donor characteristics on recipients have not been evaluated in transfusion medicine.OBJECTIVE To analyze the association of RBC donor age and sex with the survival of transfusion recipients.DESIGN, SETTING, AND PARTICIPANTS We established a longitudinal cohort by linking data from a blood collection agency with clinical and administrative data at 4 academic hospitals.MAIN OUTCOMES AND MEASURES Cox proportional hazards regression models were fitted to evaluate the risk of donor age and sex on transfusion recipient survival.RESULTS Between October 25, 2006, and December 31, 2013, a total of 30 503 RBC transfusion recipients received 187 960 RBC transfusions from 80 755 unique blood donors. For recipients receiving an RBC unit from younger donors, the risk of death was increased compared with recipients receiving an RBC unit from a donor 40 to 49.9 years old (adjusted hazard ratio, 1.08; 95% CI, 1.06-1.10; P