Altered amplitude of low frequency fluctuations in schizophrenia patients with persistent auditory verbal hallucinations
Altered amplitude of low frequency fluctuations in schizophrenia patients with persistent auditory verbal hallucinations
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DOI：
10.1016/j.schres.2017.01.042
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发表时间：
2017-11-01
影响因子：
4.5
通讯作者：
Corripio, Iluminada
中科院分区：
文献类型：
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作者：
Alonso-Solis, Anna;Vives-Gilabert, Yolanda;Corripio, Iluminada
本研究的目的是分析有或没有幻听（AVH）的精神分裂症患者低频波动（LFF）值的差异。 19 名持续性 AVH 精神分裂症患者 (HP)、14 名非幻觉精神分裂症患者 (nHP) 和 20 名健康对照者 (HC) 接受了 R-fMRI。 LFF 值是在慢频带（0.01-0.08 Hz）中计算的。通过组级别对比，我们进行了直接体素组比较。与HC相比，两组患者枕极和舌回的LFF振幅（ALFF）值均降低，而颞极和梭状回的ALFF值升高。与正常人相比，精神分裂症患者的楔前叶、枕极和双侧枕叶皮质的 ALFF 分数 (fALFF) 值降低，岛叶的 fALFF 值升高。患有和不患有 AVH 的患者之间也存在差异。 （可以从小写开始吗？）与 nHP 和 HC 相比，HP 中壳核和岛皮层的 fALFF 值较高，额极较低。与 nHP 患者和 HC 相比，HP 患者双侧丘脑和双侧海马旁回 ALFF 增加。我们的结果表明，低频波动的动态变化可能在幻听的神经生理学中发挥关键作用。 (C) 2017 Elsevier B.V. 保留所有权利。
The aim of this study is to analyze the differences in low frequency fluctuation (LFF) values between schizophrenia patients with and without auditory verbal hallucinations (AVH). Nineteen schizophrenia patients with persistent AVH (HP), fourteen non-hallucinating schizophrenia patients (nHP) and twenty healthy controls (HC) underwent R-fMRI. LFF values were calculated in the slow frequency band (0.01-0.08 Hz). By means of group level contrasts, we performed direct voxel-wise group comparisons. Both groups of patients showed decreased amplitude LFF (ALFF) values in the occipital pole and lingual gyrus compared to HC, whereas increased ALFF values were found in the temporal pole and fusifom gyrus. Schizophrenia patients exhibited decreased fractional ALFF (fALFF) values in the precuneus, occipital pole and bilateral occipital cortex, and increased fALFF in the insula compared to HC. There were also differences between patients with and without AVH. (Ok to start with lower case?) fALFF values were higher in the putamen and insular cortex and lower in the frontal pole in HP compared to nHP and HC. ALFF increased in HP patients in the bilateral thalamus and bilateral parahippocampal gyrus, compared to nHP patients and HC. Our results suggest that altered dynamics in low-frequency fluctuations may play a key role in the neurophysiology of auditory hallucinations. (C) 2017 Elsevier B.V. All rights reserved.