The morphological development of the human fovea.
The morphological development of the human fovea.
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DOI：
10.1016/s0161-6420(84)34247-6
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发表时间：
1984-06
期刊：
影响因子：
13.7
通讯作者：
A. Hendrickson;Cristine Yuodelis
中科院分区：
文献类型：
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作者：
A. Hendrickson;Cristine Yuodelis
使用醛固定的、塑料包埋的、连续切片的正常视网膜，追踪了从怀孕22周到产后45个月的人类中心凹的发育。在这项研究中使用了五个反映中心凹成熟度的解剖学指标：中心凹曲率的形状；Chievitz瞬变层的存在；中央视网膜无杆区的宽度；单个中心凹视锥的宽度和长度；以及中心凹内核层的数量和厚度。未来的中央凹在22周时可以通过存在一层厚厚的神经节细胞和只含有视锥细胞的光感受器层来识别。到出生后1周，黄斑中心凹较浅，但厚的视锥细胞仍然缺乏外节，在中心凹深处只有一个细胞。内核层包含一层厚厚的切维兹瞬变层。根据这些解剖学标准的判断，与正常的成人中心凹相比，人类的中心凹在15到45个月龄之间达到成熟。
The development of the human fovea has been traced from 22 weeks gestation to 45 months postpartum using aldehyde-fixed, plastic embedded, serially-sectioned normal retinas. Five anatomical indicators of foveal maturity were used in this study: the shape of the foveal curvatures; the presence of the transient layer of Chievitz; the width of rod-free zone in the central retina; the width and length of the individual foveal cones; and the number and thickness of layers of nuclei within the fovea. The future fovea is identifiable at 22 weeks by the presence of a thick layer of ganglion cells and a photoreceptor layer containing only cones. By 1 week after birth, there is a shallow foveal depression, but the thick cones still lack outer segments and are only 1 cell deep in the fovea. The inner nuclear layer contains a thick transient layer of Chievitz. As judged by these anatomical criteria and compared to normal adult foveas similarly processed, the human fovea reaches maturity between 15 and 45 months of age.