Occult hepatitis B virus infection and surgical outcomes in non-B, non-C patients with curative resection for hepatocellular carcinoma.
Occult hepatitis B virus infection and surgical outcomes in non-B, non-C patients with curative resection for hepatocellular carcinoma.
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DOI：
10.4254/wjh.v9.i35.1286
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发表时间：
2017-12-18
影响因子：
2.4
通讯作者：
Noshiro H
中科院分区：
文献类型：
--
作者：
Koga H;Kai K;Aishima S;Kawaguchi A;Yamaji K;Ide T;Ueda J;Noshiro H
探讨非B、非C（NBNC）肝细胞癌（HCC）患者隐匿性B型肝炎病毒（HBV）感染（OBI）的发生率、临床病理特征及手术疗效。本研究回顾性研究了78例NBNC患者的肝癌根治性切除术的情况下，DNA可以提取福尔马林固定石蜡包埋组织。OBI通过TaqMan实时聚合酶链反应至少两组不同引物的HBV-DNA扩增来确定。检查了可能的致癌因素，如酗酒、糖尿病、肥胖和非酒精性脂肪性肝炎（NASH）。根据无病生存期（DFS）、总生存期（OS）和疾病特异性生存期（DSS）评价手术疗效。在27/78例NBNC HCC患者（34.6%）中发现了OBI。OBI患者在手术时明显年轻于非OBI病例（平均年龄63.0 vs 68.1，P = 0.0334），与非OBI病例相比，OBI病例与其他病因重叠的频率明显更高（P = 0.0057）。OBI对DFS、OS或DSS没有影响。只有肿瘤相关因素影响这些手术结果。我们的研究结果表明，OBI对手术结局没有影响。NBNC HCC的手术结果取决于早期肿瘤检测;这再次证实了定期体检对具有NBNC HCC风险因素的个体的重要性。
To investigate the prevalence, clinicopathological characteristics and surgical outcomes of occult hepatitis B virus (HBV) infection (OBI) in patients with non-B, non-C (NBNC) hepatocellular carcinoma (HCC). This study retrospectively examined the cases of 78 NBNC patients with curative resection for HCC for whom DNA could be extracted from formalin-fixed paraffin-embedded tissue. OBI was determined by the HBV-DNA amplification of at least two different sets of primers by TaqMan real-time polymerase chain reaction. Possibly carcinogenetic factors such as alcohol abuse, diabetes mellitus, obesity and non-alcoholic steatohepatitis (NASH) were examined. Surgical outcomes were evaluated according to disease-free survival (DFS), overall survival (OS) and disease-specific survival (DSS). OBI was found in 27/78 patients (34.6%) with NBNC HCC. The OBI patients were significantly younger than the non-OBI cases at the time of surgery (average age 63.0 vs 68.1, P = 0.0334) and the OBI cases overlapped with other etiologies significantly more frequently compared to the non-OBI cases (P = 0.0057). OBI had no impact on the DFS, OS or DSS. Only tumor-related factors affected these surgical outcomes. Our findings indicate that OBI had no impact on surgical outcomes. The surgical outcomes of NBNC HCC depend on early tumor detection; this reconfirms the importance of a periodic medical examination for individuals who have NBNC HCC risk factors.