Generation of lndoles with Agrochemical Significance through Biotransformation by Chaetomium globosum
Generation of lndoles with Agrochemical Significance through Biotransformation by Chaetomium globosum
复制标题
通过球毛壳菌生物转化产生具有农用化学意义的吲哚
DOI：
10.1021/acs.jnatprod.8b01101
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发表时间：
2019
影响因子：
5.1
通讯作者：
Tan Ren Xiang
中科院分区：
文献类型：
--
作者：
Yan Wei;Zhao Shuang Shuang;Ye Yong Hao;Zhang Yang Yang;Zhang Yue;Xu Jia Yun;Yin Sheng Mei;Tan Ren Xiang
六种新的 (1-6) 和两种已知的 (7 和 8) 吲哚生物碱是由海洋鱼类来源的真菌 Chaetomium globosum1C51 通过生物转化产生的。通过 MS、NMR 和 X 射线晶体学分析相结合，阐明了这些生物碱的结构。 Chaetoindolone A (1) 在体外和体内均能抑制水稻病原菌 Xanthomonas oryzaepv.oryzae(xoo) 的生长。 Chaetogline A (7) 被发现对核盘菌（一种引起油菜核盘腐烂的病原体）具有杀菌作用。总的来说，这项工作提供了获得具有潜在农业化学意义的新吲哚生物碱的途径。
Six new (1–6) and two known (7and8) indole alkaloids were produced by the marine fish-derived fungusChaetomium globosum1C51 through biotransformation. The structures of these alkaloids were elucidated by a combination of MS, NMR, and X-ray crystallography analyses. Chaetoindolone A (1) was shown to inhibit the growth of the rice-pathogenic bacteriaXanthomonas oryzaepv.oryzae(xoo) both in vitro and in vivo. Chaetogline A (7) was found to be fungicidal againstSclerotinia sclerotiorum, a pathogen causing rape sclerotinia rot. Collectively, this work provides access to new indole alkaloids with potential agrochemical significance.