Importance of molecular studies on major blood groups - Intercellular adhesion molecule-4, a blood group antigen involved in multiple cellular interactions
Importance of molecular studies on major blood groups - Intercellular adhesion molecule-4, a blood group antigen involved in multiple cellular interactions
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DOI：
10.1016/j.bbagen.2007.09.003
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发表时间：
2008-03-01
影响因子：
3
通讯作者：
Gahmberg, Carl G.
中科院分区：
文献类型：
--
作者：
Toivanen, Anne;Ihanus, Evehina;Gahmberg, Carl G.
在上个世纪上半叶发现了几种血型，包括LW-血型，但它们的生化特征和细胞功能直到最近才被阐明。LW血型，重命名为ICAM-4（CD 242），是红细胞特异性的，属于细胞间粘附分子家族。ICAM-4与血液和内皮细胞上的几种整联蛋白受体结合，因此能够形成含有红细胞的大细胞复合物。其生理功能尚未完全了解，但最近的工作表明，巨噬细胞整合素可以通过这种配体结合红细胞。在这篇文章中，我们讨论了主要血型抗原的分子特性，更详细地描述了ICAM-4，并表明衰老红细胞的吞噬作用部分依赖于ICAM-4/β（2）-整合素。(c)2007 Elsevier B. V.保留所有权利。
Several blood groups, including the LW-blood group were discovered in the first part of last century, but their biochemical characteristics and cellular functions have only more recently been elucidated. The LW-blood group, renamed ICAM-4 (CD242), is red cell specific and belongs to the intercellular adhesion molecule family. ICAM-4 binds to several integrin receptors on blood and endothelial cells and is thus able to form large cellular complexes containing red cells. Its physiological function(s) has remained incompletely understood, but recent work shows that macrophage integrins can bind red cells through this ligand. In this article we discuss molecular properties of major blood group antigens, describe ICAM-4 in more detail, and show that phagocytosis of senescent red cells is in part ICAM-4/beta(2)-itegrin dependent. (c) 2007 Elsevier B.V. All rights reserved.