A novel network of multipolar bursting interneurons generates theta frequency oscillations in neocortex
A novel network of multipolar bursting interneurons generates theta frequency oscillations in neocortex
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DOI：
10.1016/s0896-6273(03)00300-3
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发表时间：
2003-06-05
期刊：
影响因子：
16.2
通讯作者：
Monyer, H
中科院分区：
文献类型：
--
作者：
Blatow, M;Rozov, A;Monyer, H
GABA能中间神经元可以将主要细胞的输出阶段，从而在不同的频带中产生振荡活性。在这里，我们描述了小鼠新皮层中多极爆发（MB）细胞的GABA能中间神经元的新亚型。 MB细胞为白蛋白阳性，但与快速刺激的多极（FS）细胞不同，其形态学，神经化学和生理特性。 MB细胞与2/3层锥体细胞相互连接，并通过化学和电突触相互耦合。 MB细胞支配FS细胞，但反之亦然。 MB到MB细胞以及MB到锥体细胞突触表现出配对的脉冲促进。卡巴醇在MB细胞中选择性诱导的同步theta频率振荡。同步需要间隙连接耦合和GABA能化学传输，但不需要兴奋性谷氨酸能输入。因此，MB细胞形成一个独特的抑制网络，在胆碱能驱动器上可以产生节奏和同步的theta频率活动，从而提供了锥体细胞输出的时间协调。
GABAergic interneurons can phase the output of principal cells, giving rise to oscillatory activity in different frequency bands. Here we describe a new subtype of GABAergic interneuron, the multipolar bursting (MB) cell in the mouse neocortex. MB cells are parvalbumin positive but differ from fast-spiking multipolar (FS) cells in their morphological, neurochemical, and physiological properties. MB cells are reciprocally connected with layer 2/3 pyramidal cells and are coupled with each other by chemical and electrical synapses. MB cells innervate FS cells but not vice versa. MB to MB cell as well as MB to pyramidal cell synapses exhibit paired-pulse facilitation. Carbachol selectively induced synchronized theta frequency oscillations in MB cells. Synchrony required both gap junction coupling and GABAergic chemical transmission, but not excitatory glutamatergic input. Hence, MB cells form a distinct inhibitory network, which upon cholinergic drive can generate rhythmic and synchronous theta frequency activity, providing temporal coordination of pyramidal cell output.