Association of hexachlorobenzene and other organochlorine compounds with anthropometric measures at birth
Association of hexachlorobenzene and other organochlorine compounds with anthropometric measures at birth
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DOI：
10.1023/01.pdr.0000023171.89966.8b
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发表时间：
2002-08-01
影响因子：
3.6
通讯作者：
Sunyer, J
中科院分区：
文献类型：
--
作者：
Ribas-Fitó, N;Sala, M;Sunyer, J
本研究的目的是评估产前接触六氯苯和其他有机氯化合物与出生时人体测量的关系。在给予书面同意后，共招募了98对母婴（占1997-1999年期间在受六氯苯污染的特定地区出生的所有儿童的83%）。对72份分娩时的母体血清样本和70份脐带血清样本中的有机氯化合物水平进行了测量。在脐带血清中测得的有机氯中，六氯苯的中位数水平高于其他化合物（六氯苯的中位数= 1.13纳克/毫升，二氯二苯二氯乙烯的中位数= 0.85纳克/毫升，多氯联苯总量的中位数= 0.27纳克/毫升）。早产新生儿脐带血中六氯苯浓度较高[早产儿为1.94纳克/毫升，非早产儿为1.10纳克/毫升（p < 0.10）]，二氯二苯二氯乙烯浓度较高[2.40纳克/毫升，非早产儿为0.80纳克/毫升（p < 0.05）]，多氯联苯浓度较高[0.70纳克/毫升，非早产儿为0.14纳克/毫升（p < 0.10）]。出生时身长小于胎龄儿的脐带血中六氯苯水平高于身长大于胎龄儿的脐带血[1.64 ng/mL vs 1.00 ng/mL（p < 0.05）]。此外，在调整吸烟、胎龄和其他有机氯化合物后，六氯苯脐带血清水平与冠踵长度呈剂量-反应负相关[剂量每增加一倍，减少0.46（SE = 0.22）cm]。二氯二苯二氯乙烯和多氯联苯与体长的相关性不显著。结果没有变化时，分层早产。这些数据表明，六氯苯会降低子宫内的身体线性生长。
The aim of the present study was to assess the association of prenatal exposure to hexachlorobenzene (HCB) and other organochlorine compounds with anthropometric measures at birth. A total of 98 mother-infant pairs (83% of all children born in a specific area polluted with HCB in the period 1997-1999) were recruited after giving written consent. Levels of organochlorine compounds were measured in 72 maternal serum samples at delivery and in 70 cord serum samples. Of the organochlorines measured in cord serum, median levels of HCB were higher than for the other compounds (median of HCB = 1.13 ng/mL, median of dichlorodiphenyl dichloroethylene = 0.85 ng/mL, and median of total polychlorinated biphenyls = 0.27 ng/mL). Premature newborns had higher concentrations of HCB [1.94 ng/mL among prematures versus 1.10 among nonprematures (p < 0.10)], dichlorodiphenyl dichloroethylene [2.40 versus 0.80 (p < 0.05)], and polychlorinated biphenyls in cord serum [0.70 versus 0.14 (p < 0.10)]. Those infants born with a small length for gestational age had higher levels of HCB in cord serum than those with an adequate length for gestational age [1.64 ng/mL versus 1.00 ng/mL (p < 0.05)]. In addition, HCB cord serum levels were negatively associated in a dose-response way with crown-heel length [for each doubling of the dose there was a decrease of 0.46 (SE = 0.22) cm] after adjusting for smoking, gestational age, and other organochlorine compounds. The associations of dichlorodiphenyl dichloroethylene and polychlorinated biphenyls with length were not significant. The results did not vary when stratified for prematurity. These data suggest that HCB reduces intrauterine physical linear growth.