Pharmacokinetics of Probiotics and Biotherapeutic Agents in Humans
Pharmacokinetics of Probiotics and Biotherapeutic Agents in Humans
复制标题
益生菌和生物治疗药物在人体中的药代动力学
DOI：
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发表时间：
1998
期刊：
影响因子：
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通讯作者：
T. Vesa
中科院分区：
文献类型：
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作者：
P. Marteau;T. Vesa
益生菌或生物制剂可以通过在胃肠道中发生的直接或间接作用来影响生理学。需要了解它们的药代动力学：1）回答应该摄入多少益生菌的问题，多久一次？多长时间？2)将效果与目标部位益生菌的浓度关联起来; 3）验证假设，例如“益生菌应该是人类来源的，..有很强的生存能力，...粘附在肠上皮细胞上”......; 4)预测其他益生菌的作用; 5）确定商业制剂中应存在的浓度; 6）安全性。已经开发了一些体外模型来预测益生菌在体内的存活或它们对肠上皮的粘附，然而，建立益生菌药代动力学的最佳方法是在体内测量它。可使用三种技术：粪便收集、pixigraphy和肠插管。有必要使用转运标记物，如嗜热脂肪芽孢杆菌的孢子，以研究益生菌定殖的潜力（即比惰性标记物持续更长的时间）。本文综述了益生菌药代动力学的研究进展。一些菌株可以粘附于细胞系如CaCo 2或HT 29。摄入的益生菌的存活率在属和菌株之间差异很大。一些菌株在胃中迅速被破坏，而其他菌株如双歧杆菌或乳杆菌则存活至粪便。
Probiotics or biotherapeutic agents can influence physiology through direct or indirect effects occurring in the gastrointestinal tract. Knowledge on their pharmacokinetics is needed 1) to answer the questions how much probiotic should be consumed?, how often?, how long?; 2) to correlate the effects with the concentration of the probiotic at the target site; 3) to validate hypotheses such as "a probiotic should be of human origin, ... have a high survival capacity, ... adhere to the intestinal epithelium" ...; 4) to anticipate the effects of other probiotics; 5) to establish what concentrations should be present in the commercial preparations; 6) for safety. Some in vitro models have been developed to predict the survival of probiotics in vivo or their adherence to the intestinal epithelium, however, the best way to establish the pharmacokinetics of a probiotic is to measure it in vivo. Three techniques can be used: collection of feces, pixigraphy, and intestinal intubation. The use of transit markers such as spores of Bacillus stearothermophilus is necessary to study the potential for probiotics to colonize (i.e. to persist for longer period than the inert marker). Knowledge on the pharmacokinetics of probiotics is reviewed. Some strains can adhere to cell lines such as CaCo2 or HT29. The survival of ingested probiotics differs greatly between genus and strains. Some strains are rapidly destroyed in the stomach while others such as some Bifidobacterium sp. or Lactobacillus sp. survive till feces.
喂给人类的外源性乳酸杆菌 - 它们的命运和预防腹泻病的能力。
DOI：
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发表时间：
1983
期刊：
Progress in food & nutrition science
影响因子：
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作者：
Clements,ML;Levine,MM;Ristaino,PA;Daya,VE;Hughes,TP
通讯作者：
Hughes,TP