Differences in characteristics of somatosensory evoked potentials between children and adults
Differences in characteristics of somatosensory evoked potentials between children and adults
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儿童与成人体感诱发电位特征的差异
DOI：
10.1097/wnr.0000000000001355
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发表时间：
2019
期刊：
影响因子：
1.7
通讯作者：
Nakata H
中科院分区：
文献类型：
--
作者：
Takezawa M;Kamijo K;Shibasaki M;Nakata H
本研究探讨了健康青春期前儿童（平均年龄：124.9±3.8个月）与年轻成人相比的体感加工特征。以3 Hz频率电刺激右侧正中神经，记录额（Fz）和顶中央（C3′）电极的体感诱发电位。两组C3′体感诱发电位波形特征差异显著，Fz体感诱发电位波形特征相似。儿童C3′的波形不仅包括标准的P12、N18、P22、N27、P45和N60成分，而且还包括介于N27和P45之间的额外的正（P3）和负（N3）成分，而成人中没有发现这些成分。儿童C3′ P22波幅显著大于成人，提示躯体感觉加工的神经活动具有高度兴奋性/反应性。相反，儿童的N15在Fz和N27在C3′的振幅小于成人，表明儿童的躯体感觉系统不成熟。儿童Fz的P12、N15、P18峰潜伏期及C3′的P12、N18峰潜伏期均短于成人，且与身高有关。这些结果表明，发育中的躯体感觉加工与高和低兴奋性的神经活动在青春期前的儿童。
The present study examined the characteristics of somatosensory processing in healthy prepubescent children (mean age: 124.9±3.8 months) compared with young adults. Somatosensory evoked potentials at the frontal (Fz) and centroparietal (C3′) electrodes were recorded by delivering an electrical stimulus to the right median nerve at a rate of 3 Hz. The characteristics of somatosensory evoked potential waveforms at C3′ were markedly different between the two groups, while those at Fz were similar. Specifically, the waveforms at C3′ in the children involved not only standard P12, N18, P22, N27, P45, and N60 components, but also additional positive (P3) and negative (N3) components between N27 and P45, which were not found in adults. The amplitude of P22 at C3′ was significantly larger in the children than adults, indicating hyper-excitability/responsiveness of neural activity on somatosensory processing. In contrast, the amplitudes of N15 at Fz and N27 at C3′ were smaller in the children than adults, suggesting an immature somatosensory system in the children. The peak latencies of P12, N15, and P18 at Fz, and P12 and N18 at C3′ were significantly shorter in the children than adults, which was dependent on the height. These results indicate the developing somatosensory processing with hyper-and hypo-excitability of neural activity in prepubescent children.