The intake of grain fibers modulates cytokine levels in blood
The intake of grain fibers modulates cytokine levels in blood
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DOI：
10.3109/1354750x.2011.599042
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发表时间：
2011-09-01
期刊：
影响因子：
2.6
通讯作者：
Vineis, Paolo
中科院分区：
文献类型：
--
作者：
Chuang, Shu-Chun;Vermeulen, Roel;Vineis, Paolo
膳食纤维可以调节肠腔环境，改变肠道微生物群落，并影响免疫反应和疾病风险。流行病学调查表明，较高的纤维摄入量与较低的总体死亡率有关，特别是心血管和消化道疾病。在此，在意大利EPIC-Italy队列中采样的88名无癌症受试者的血浆中测量了一组17种细胞因子和趋化因子。在因子分析中，谷物纤维和主要因子中包括的细胞因子（IL-1 β、IL-4、IL-5、IL-6、IL-13和TNF-α）观察到统计学显著的负相关（p趋势= 0.01），仅这一项就解释了35.5%的方差。我们的研究表明，纤维摄入，特别是谷物纤维，可能与促炎细胞因子水平降低有关。
Dietary fiber may modulate the environment of the intestinal lumen, alter the intestinal microflora populations, and influence the immune response and disease risk. Epidemiological investigations have suggested that higher fiber intake is associated with lower overall mortality, in particular from cardiovascular and digestive tract diseases. Here a panel of 17 cytokines and chemokines were measured in plasma of 88 cancer-free subjects sampled within the Italian EPIC-Italy cohort. A statistically significant inverse association (p-trend = 0.01) was observed for cereal fiber and cytokines included in the main factor in factor analysis (IL-1 beta, IL-4, IL-5, IL-6, IL-13, and TNF-alpha), which alone explained 35.5% of variance. Our study suggests that fiber intake, especially cereal fiber, may be associated with a decreased level of pro-inflammatory cytokines.