GABA neuron systems in hypothalamus and the pituitary gland. Immunohistochemical demonstration using antibodies against glutamate decarboxylase.
GABA neuron systems in hypothalamus and the pituitary gland. Immunohistochemical demonstration using antibodies against glutamate decarboxylase.
复制标题
下丘脑和垂体中的 GABA 神经元系统。
作者：
S. Vincent;T. Hökfelt;J. Wu
用抗γ-氨基丁酸（GABA）合成酶谷氨酸脱羧酶（GAD）的抗体，对大鼠下丘脑和垂体内GABA神经纤维和胞体的分布进行了化学分析。观察到GAD阳性神经纤维的致密网络基本上均匀地分布在整个下丘脑。在垂体正中隆起、后叶和中叶内均可见GABA终末丛。在下丘脑后部发现了三个不同的大细胞GABA神经元簇。此外，在下丘脑弓状核和穹窿周围区等许多核团也可见GAD阳性胞体。本研究结果为下丘脑来源的GABA调节神经内分泌系统提供了形态学依据。
The distribution of gamma-aminobutyric acid (GABA) nerve fibers and cell bodies in the rat hypothalamus and pituitary gland was immunohistochemically examined using antibodies against the GABA-synthesizing enzyme glutamate decarboxylase (GAD). The dense network of GAD-positive nerve fibers was observed to be essentially evenly distributed throughout the hypothalamus. A plexus of GABA terminals was also demonstrated both in the median eminence and with in the posterior and intermediate lobes of the pituitary. Three distinct clusters of magnocellular GABA neurons were discovered in the posterior hypothalamus. In the addition, GAD immunoreactive cell bodies were observed in many other hypothalamic nuclei, such as the arcuate nucleus and in the perifornical region. The results provide a morphological basis by which GABA of hypothalamic origin may regulate the neuroendocrine system.