Assessment of aerobic capacity during swimming exercise in ob/ob mice
Assessment of aerobic capacity during swimming exercise in ob/ob mice
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DOI：
10.1002/cbf.1803
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发表时间：
2011-10
影响因子：
3.6
通讯作者：
W. S. Almeida;L. C. J. Lima;V. N. Cunha;Rafael Rodrigues da Cunha;Ronaldo C. Araujo;Carlos Castilho Barros;Herbert Gustavo Simões;C. Campbell
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文献类型：
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作者：
W. S. Almeida;L. C. J. Lima;V. N. Cunha;Rafael Rodrigues da Cunha;Ronaldo C. Araujo;Carlos Castilho Barros;Herbert Gustavo Simões;C. Campbell
肥胖是一种与几种疾病相关的高度流行的疾病。体育锻炼一直被认为是治疗肥胖症的一种非药物手段。然而，肥胖症的运动评估和处方的几个方面以及相关的病理学仍在调查中。尽管许多涉及运动的研究已经在动物模型中进行，但对于肥胖动物，如ob/ob小鼠，缺乏评估有氧能力的方案。本研究的目的是：(I)验证通过目测(VLT)和多项式调整(PLT)来确定ob/ob小鼠和非肥胖杂合子小鼠(ob/ob)游泳运动的乳酸阈值(LT)的可能性；以及(Ii)验证通过这些方案确定的LT是否对应于最大乳酸稳定状态(MLSS)。8只ob/ob和10只ob/ob小鼠进行了递增负荷运动试验，以确定VLT和PLT，并进行了恒定负荷运动，以确定MLSS。VLT、PLT和MLSS组内无差异[ob/ob：~5.3%体重(BW)；ob/ob：~3.6%bw]，各方案间高度一致。综上所述，两组的LT和MLSS强度的识别都是可能的。这些数据表明，建议的方案可能用于新的研究，研究不同运动强度对肥胖某些方面的影响。版权所有©2011 John Wiley&Sons，Ltd.
Obesity is a highly prevalent condition associated with several diseases. Physical exercise has been considered as a non‐pharmacological tool in the treatment of obesity. However, several aspects underlying exercise evaluation and prescription in obesity and associated pathologies are still under investigation. Although many research involving exercise have been performed in animal models, there is a lack of protocols for aerobic capacity assessment in obese animals, such as the ob/ob mice. This study aimed the following: (i) to verify the possibility of determining the lactate threshold (LT) on swimming exercise in ob/ob mice and in non‐obese heterozygote mice (ob/OB), through visual inspection (vLT) and polynomial adjustment (pLT); and (ii) to verify if the LT determined through these protocols corresponds to the maximal lactate steady state (MLSS). Eight ob/ob and ten ob/OB mice performed an incremental exercise test to determine vLT and pLT as well as constant‐load exercise bouts to determine MLSS. There were no within‐group differences between vLT, pLT and MLSS [ob/ob: ~5.3% body weight (BW); ob/OB: ~3·6%BW] with a high agreement among protocols. In conclusion, the identification of the LT and MLSS intensities was possible for both groups. These data suggest that the proposed protocols may be used in new research on the effects of different exercise intensities on some aspects of obesity. Copyright © 2011 John Wiley & Sons, Ltd.