Pegylated interferon alfa 2b and oral ribavirin in patients with HCV-related cirrhosis.
Pegylated interferon alfa 2b and oral ribavirin in patients with HCV-related cirrhosis.
复制标题
聚乙二醇干扰素 α 2b 和口服利巴韦林治疗 HCV 相关肝硬化患者。
DOI：
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发表时间：
2006
影响因子：
2
通讯作者：
M. Bansal
中科院分区：
文献类型：
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作者：
A. Sood;V. Midha;N. Sood;M. Bansal
背景
丙型肝炎病毒(丙型肝炎病毒)相关性肝硬变的治疗是困难的，因为不良反应的频率很高。我们回顾了丙型肝炎肝硬变患者的病例记录，以评估聚乙二醇化干扰素和利巴韦林治疗这些患者的有效性和耐受性。
方法
本文回顾了28例丙型肝炎病毒相关性代偿性肝硬变患者的临床资料。治疗方案为聚乙二醇化干扰素α-2b(1微克/kg/周)联合利巴韦林(10~12 mg/kg/d)治疗。主要终点是持续的病毒学应答，附加终点是药物耐受性、临床或生化恶化和死亡。
结果
治疗结束后，28名患者中有24名(85%)出现了病毒学应答，28名患者中有15名(53%)出现了持续的病毒学应答。生化反应和持续反应分别为20例和16例(71%和57%)。3例患者因肝功能失代偿、1例药物不耐受而停止治疗，2例患者需要调整剂量。
结论
聚乙二醇化干扰素联合利巴韦林对肝硬变患者似乎有效。复发率高、生化恢复差和失代偿的可能性是需要牢记的问题。
BACKGROUND
The treatment of hepatitis C virus (HCV)-related cirrhosis is difficult due to high frequency of adverse effects. We retrospectively reviewed the case records of patients with HCV cirrhosis to evaluate the efficacy and tolerability of pegylated (peg) interferon and ribavirin treatment in these patients.
METHODS
Medical records of 28 patients with HCV-related compensated cirrhosis were reviewed. The treatment protocol was a combination therapy of peg interferon alfa-2b (1 microg/Kg/week) plus oral ribavirin (10-12 mg/Kg/day). Primary endpoint was sustained virological response, with additional endpoints of drug tolerance, clinical or biochemical worsening and death.
RESULTS
End-of-treatment virlogic response was seen in 24 of 28 patients (85%) and sustained virologic response in 15 of 28 (53%) patients. Biochemical end-of-treatment response and sustained response were seen in 20 and 16 patients (71% and 57%), respectively. Treatment had to be stopped in 3 patients due to decompensation of liver status in two and drug intolerance in one, while dose modification was required in two patients.
CONCLUSIONS
Combination therapy with peg interferon plus ribavirin seems effective in patients with liver cirrhosis. High relapse rate, poor biochemical recovery and possibility of decompensation are issues that need to be kept in mind.