Presence of HIV-1 gag-specific IFN-γ+IL-2+ and CD28+IL-2+ CD4 T cell responses is associated with nonprogression in HIV-1 infection
Presence of HIV-1 gag-specific IFN-γ+IL-2+ and CD28+IL-2+ CD4 T cell responses is associated with nonprogression in HIV-1 infection
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DOI：
10.4049/jimmunol.169.11.6376
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发表时间：
2002-12-01
影响因子：
4.4
通讯作者：
Vyakarnam, A
中科院分区：
文献类型：
--
作者：
Boaz, MJ;Waters, A;Vyakarnam, A
HIV免疫可能依赖于CD 4 T细胞。据报道，HIV特异性CD 4 T细胞增殖反应与病毒载量呈负相关，与特异性CD 8反应直接相关。然而，与疾病相关的特异性CD 4 T细胞的表型和细胞因子谱是未知的。我们比较了17例感染中位时间为14.6年的HIV感染长期无进展者（LTNP）和16例感染中位时间为14年但CD 4计数下降至100%的HIV感染缓慢进展者（SP）的Gag p24特异性CD 4 T细胞的数量/功能。
HIV immunity is likely CD4 T cell dependent. HIV-specific CD4 T cell proliferative responses are reported to correlate inversely with virus load and directly with specific CD8 responses. However, the phenotype and cytokine profile of specific CD4 T cells that correlate with disease is unknown. We compared the number/function of Gag p24-specific CD4 T cells in 17 HIV-infected long-term nonprogressors (LTNPs) infected for a median of 14.6 years with those of 16 slow progressors (SPs), also HIV infected for a median of 14 years but whose CD4 count had declined to