Atropine inhibits gastric distension and pharyngeal receptor mediated lower oesophageal sphincter relaxation
Atropine inhibits gastric distension and pharyngeal receptor mediated lower oesophageal sphincter relaxation
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DOI：
10.1136/gut.41.3.285
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发表时间：
1997-09-01
期刊：
影响因子：
24.5
通讯作者：
Dixon, S
中科院分区：
文献类型：
--
作者：
Mittal, RK;Chiareli, C;Dixon, S
背景-阿托品通过未知机制降低短暂性下食管括约肌松弛 (TLOSR) 的频率。胃扩张和咽部受体兴奋是导致 TLOSR 的传入刺激的两个可能来源。目的 - 确定阿托品是否影响胃部扩张引起的 TLOSR 和咽部受体介导的下食管括约肌 (LOS) 松弛。方法 - 10 名健康志愿者在餐后的两天内进行食管测压和 pH 记录，在阿托品（15 mu g/kg静脉推注和4μg/kg/h作为维持剂量）或安慰剂。通过在阿托品注射前后向咽部快速注射微量水（0.05、0.1、0.2、0.3 和 0.4 毫升），对 9 名受试者研究了咽部受体介导的 LOS 松弛。通过在阿托品治疗前后向胃中注入 300、600 和 900 毫升 CO2，对 8 名受试者进行了胃扩张介导的 TLOSR 的研究。结果-与安慰剂相比，阿托品降低了自发性胃食管反流和 TLOSR 的频率（p
Background-Atropine decreases the frequency of transient lower oesophageal sphincter relaxation (TLOSR) through an unknown mechanism. Gastric distension and pharyngeal receptor excitation are two possible sources for the afferent stimulus responsible for TLOSR.Aims-To determine whether atropine affects gastric distension induced TLOSR and pharyngeal receptor mediated lower oesophageal sphincter (LOS) relaxation.Methods-Oesophageal manometry and pH recordings were performed in 10 healthy volunteers on two separate days in the postprandial setting, following either atropine (15 mu g/kg intravenous bolus and 4 mu g/kg/h as a maintenance dose) or placebo. Pharyngeal receptor mediated LOS relaxation was studied in nine subjects by rapid injection of minute amounts of water (0.05, 0.1, 0.2, 0.3, and 0.4 ml) in the pharynx before and after atropine. Gastric distension mediated TLOSR was studied in eight subjects by insufflating the stomach with 300, 600 and 900 ml of CO2 before and after atropine.Results-Atropine reduced the frequency of spontaneous gastro-oesophageal reflux and TLOSR compared with placebo (p