ODOR STIMULI TRIGGER INFLUX OF CALCIUM INTO OLFACTORY NEURONS OF THE CHANNEL CATFISH
ODOR STIMULI TRIGGER INFLUX OF CALCIUM INTO OLFACTORY NEURONS OF THE CHANNEL CATFISH
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DOI：
10.1126/science.2168580
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发表时间：
1990-09-07
期刊：
影响因子：
56.9
通讯作者：
TEETER, JH
中科院分区：
文献类型：
--
作者：
RESTREPO, D;MIYAMOTO, T;TEETER, JH
嗅觉传导被认为是由G蛋白偶联的细胞内腺苷3“，5”-单磷酸（cAMP）的增加介导的，其触发cAMP门控阳离子通道的开放并导致嗅觉神经元的质膜的去极化。在从癍点叉尾鮰分离的嗅觉神经元中，用嗅觉刺激物（氨基酸）刺激可引起钙离子的流入，从而导致细胞内钙离子的快速增加。此外，在重建试验中，已鉴定出质膜钙通道由肌醇-1，4，5-三磷酸（IP 3）门控，其可介导该钙内流。与以前的研究表明，刺激嗅觉刺激导致嗅觉纤毛的磷酸肌醇营业额stimation，这些数据表明，钙离子的流入引发的气味刺激磷酸肌醇营业额可能是一种替代或额外的嗅觉转导机制。
Olfactory transduction is thought to be mediated by a G protein-coupled increase in intracellular adenosine 3'',5''-monophosphate (cAMP) that triggers the opening of cAMP-gated cation channels and results in depolarization of the plasma membrane of olfactory neurons. In olfactory neurons isolated from the channel catfish, Ictalurus punctatus, stimulation with olfactory stimuli (amino acids) elicits an influx of caclium that leads to a rapid increase in intracellular calcium. In addition, in a reconstitution assay a plasma membrane calcium channel has been identified that is gated by inositol-1,4,5-trisphosphate (IP3), which could mediate this calcium influx. Together with previous studies indicating that stimulation with olfactory stimuli leads to stimation of phosphoinositide turnover in olfactory cilia, these data suggest that an influx of calcium triggered by odor stimulation of phosphoinositide turnover may be an alternate or additional mechanism of olfactory transduction.