Sex differences in Sjögren's syndrome: a comprehensive review of immune mechanisms.
Sex differences in Sjögren's syndrome: a comprehensive review of immune mechanisms.
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DOI：
10.1186/s13293-015-0037-7
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发表时间：
2015
影响因子：
7.9
通讯作者：
Fairweather D
中科院分区：
文献类型：
--
作者：
Brandt JE;Priori R;Valesini G;Fairweather D
据估计，自身免疫性疾病（AD）影响5%至8%的美国人口，其中约80%的患者为女性。干燥综合征（SS）是一种AD，主要发生在女性而不是男性（16：1）。SS的标志性特征是初级外分泌腺和泪腺或唾液腺分泌减少，导致干眼症和口干症状。这种疾病被认为是由针对唾液腺和泪腺组织的炎症和自身抗体反应介导的。本综述将研究文献的性别差异的免疫反应的患者和动物模型的干燥综合征，以获得更好地了解疾病的发病机制。
Autoimmune diseases (ADs) are estimated to affect between 5 and 8 % of the US population, and approximately 80 % of these patients are women. Sjögren’s syndrome (SS) is an AD that occurs predominately in women over men (16:1). The hallmark characteristic of SS is diminished secretory production from the primary exocrine gland and the lacrimal or salivary glands resulting in symptoms of dry eye and mouth. The disease is believed to be mediated by an inflammatory and autoantibody response directed against salivary and lacrimal gland tissues. This review will examine the literature on sex differences in the immune response of patients and animal models of Sjögren’s syndrome in order to gain a better understanding of disease pathogenesis.