Longus pilus of enterotoxigenic Escherichia coli and its relatedness to other type-4 pili - A minireview
Longus pilus of enterotoxigenic Escherichia coli and its relatedness to other type-4 pili - A minireview
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DOI：
10.1016/s0378-1119(97)00039-5
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发表时间：
1997-06-11
期刊：
影响因子：
3.5
通讯作者：
Kaper, JB
中科院分区：
文献类型：
--
作者：
Giron, JA;GomezDuarte, OG;Kaper, JB
长菌毛（Longus）是由人产肠毒素大肠杆菌（ETEC）产生的一种长菌毛，其结构和生化特征与B类4型皮利相似。这些皮利包括霍乱弧菌的毒素协同调节菌毛（TCP）、肠致病性大肠杆菌的肠形成菌毛（BFP）和肠致病性大肠杆菌的肠形成菌毛（BFP）。大肠杆菌和大肠杆菌长杆菌以及ETEC的定植因子抗原III（CFA/III）。这些皮利是在确定的生长条件下产生的，表明它们是在不同调节元件的控制下。虽然TCP是染色体编码的，但剩余的皮利在大的毒力质粒上编码。Longus和CFA/III的皮利密切相关，尽管它们之间也存在某些DNA和蛋白质差异。这可能解释了ETEC中这两种菌毛蛋白的调节、表面呈递、抗原性和流行率的差异。与lngA相邻的第二个开放阅读框称为lngB，其编码的蛋白质与II型分泌系统的一部分，如铜绿假单胞菌、欧文氏菌和肺炎克雷伯氏菌的XcpV、OutC和普洛具有显著同源性。这表明lngB可能是参与长肌生物发生的辅助基因。(C)1997年Elsevier Science B.V.
Longus is a long pilus produced by human enterotoxigenic Escherichia coli (ETEC) which shares significant structural and biochemical features with class-B type-4 pili. These pili include the toxin-coregulated pilus (TCP) of Vibrio cholerae, the bundle-forming pilus (BFP) of enteropathogenic E. coli and both longus and the colonization factor antigen III (CFA/III) of ETEC. These pili are produced under defined growth conditions indicating that they are under the control of different regulatory elements. While TCP is chromosomally encoded, the remaining pili are encoded on large virulence plasmids. Longus and CFA/III are closely related pili although certain DNA and protein differences also exist between them. This may account for the differences in the regulation, surface presentation, antigenicity, and prevalence of these two pilins among ETEC. Neighboring lngA, a second open reading frame termed lngB was found which encodes a protein with significant homology to proteins which are part of a type-II secretory system such as XcpV, OutC, and PulO of Pseudomonas aeruginosa, Erwinia chrysanthemi, and Klebsiella pneumoniae, respectively. This suggests that lngB may be an accessory gene involved in biogenesis of longus. (C) 1997 Elsevier Science B.V.