Red cells in sickle cell crisis: observations on the pathophysiology of crisis.
Red cells in sickle cell crisis: observations on the pathophysiology of crisis.
复制标题
镰状细胞危象中的红细胞：危象病理生理学观察。
DOI：
10.1182/blood.v49.6.967.bloodjournal496967
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发表时间：
1977
期刊：
影响因子：
20.3
通讯作者：
S. Pollack
中科院分区：
文献类型：
--
作者：
E. Rieber;G. Veliz;S. Pollack
镰状细胞危象发生和解决的病理生理学尚不清楚。分子异常是持续存在的，而危机却是偶发的。在本研究中，测量了镰状细胞危机期间的红细胞过滤性和脱氧镰状化。从镰状细胞危象中恢复与循环红细胞的过滤性增加以及红细胞对脱氧镰状细胞的敏感性降低有关（p小于0.05）。有人提出这些变化可能是解决危机的原因。
The pathophysiology of the occurrence and resolution of sickle cell crisis is unknown. The molecular abnormality is constant, while crisis is episodic. In the present study, red cell filterability and sickling with deoxygenation have been measured during sickle cell crises. Recovery from sickle crisis is associated with an increased filterability of the circulating red cell and a decreased susceptibility of the red cell to sickle with deoxygenation (p less than 0.05). The possibility that these changes are responsible for the resolution of crisis is suggested.