Cactus Alkaloids. XLVI. 3-Methoxytyramine and Lemaireocereine From Backebergia militaris
Cactus Alkaloids. XLVI. 3-Methoxytyramine and Lemaireocereine From Backebergia militaris
复制标题
仙人掌生物碱。
DOI：
10.1021/np50016a021
复制
发表时间：
1981
影响因子：
5.1
通讯作者：
J. McLaughlin
中科院分区：
文献类型：
--
作者：
S. Pummangura;J. McLaughlin
通过质量分析离子动能谱（MIKES）筛选墨西哥仙人掌 Backebergia militaris (Andot) Bravo ex Sanchez Mejorada 的提取物，结果显示存在 (M+ H)+ 194 和 208 生物碱； MIKES 筛选中未找到分子量小于 193 的生物碱 (1)。在随后的分离研究中，3, 4-二甲氧基-/3-苯乙胺,(1)（分子量 181）和苏醒胺,(2)(6, 7-二甲氧基-1, 2, 3, 4-四氢异喹啉)（分子量 193）从植物材料中结晶，产率分别为 0.025% 和 0.75% （2）。在使用分析薄层色谱 (tic)(3) 对该物种的提取物进行更仔细的筛选时，在生物碱提取物中检测到少量的附加仲胺 3。柱吸附色谱成功地从 1 和 2 中分离出 3。与参考仙人掌生物碱比较，确定 3 的结晶盐酸盐为 lemaireocereine (7, 8-dimethoxy-
Screening extracts of theMexican cereoid cactus, Backebergia militaris (Andot) Bravo ex Sanchez Mejorada, by mass-analyzed ion kinetic energy spectrometry (MIKES), showed the presence of alkaloids of (M+ H)+ 194 and 208; alkaloids of molecular weight less than 193 were not sought in the MIKES screen(1). In a subsequent isolation study, 3, 4-dimethoxv-/3-phenethylamine,(1)(m. wt. 181), and heliamine,(2)(6, 7-dimethoxy-1, 2, 3, 4-tetrahydroisoquinoline)(m. wt. 193), were crystallized in respective yields of 0.025% and 0.75% from the plant material (2). In a closer screening of extracts of this species with analytical thin layer chromatography (tic)(3), an addi-tional secondary amine, 3, was de-tected in small quantity inthe alkaloid extracts. Column adsorption chromatography successfully resolved 3 from 1 and 2. Comparisons with reference cactus alkaloids identified the crystalline hydrochloride of 3 as that of lemaireocereine (7, 8-dimethoxy-