The impact of population level deworming on the haemoglobin levels of schoolchildren in Tanga, Tanzania
The impact of population level deworming on the haemoglobin levels of schoolchildren in Tanga, Tanzania
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DOI：
10.1046/j.1365-3156.1999.00486.x
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发表时间：
1999-11-01
影响因子：
3.3
通讯作者：
Bundy, DAP
中科院分区：
文献类型：
--
作者：
Beasley, NMR;Tomkins, AM;Bundy, DAP
根据贫血（血红蛋白浓度< 11.0 g/dl）和钩虫卵负荷量重（> 5000 epg）或轻（<5000 epg），将阿苯达唑（400 mg）和吡喹酮（40 mg/kg体重）治疗对学龄儿童的影响与安慰剂进行了比较。这项研究是在农村坦加进行的。1994年9月开始用药，1995年1月对儿童进行了随访。总的来说，驱虫治疗减少了血红蛋白浓度的下降，与安慰剂组相比（-0.11 g/dl vs.-0.35 g/dl; P = 0.02）。驱虫治疗对9%的贫血和钩虫卵负荷重的儿童（+ 0.67 g/dl vs. - 0.67 g/dl）获益最大，对38%的贫血和钩虫卵负荷轻的儿童（+ 0.07 g/dl vs. - 0.21 g/dl）也有显著获益。对没有贫血的儿童没有明显的益处。这项研究表明，在该地区的学校分发的单剂量驱虫剂治疗对近一半感染了沙门氏菌的儿童的血液学有益。寄生虫和土蠕虫（占总人口的37%）。
The impact of albendazole (400 mg) and praziquantel (40 mg/kg body weight) treatment of schoolchildren was compared with placebo according to the presence of anaemia (haemoglobin concentration < 11.0 g/dl) and heavy (> 5000 epg) or light (< 5000 epg) hookworm egg load. The study was conducted in rural Tanga. Medication was administered in September 1994 and children were followed-up in January 1995. Overall, anthelminthic treatment reduced the fall in haemoglobin concentration compared with that observed in the placebo group (- 0.11 g/dl vs. - 0.35 g/dl; P = 0.02). Anthelminthic treatment was of greatest benefit to the 9% of children with both anaemia and heavy hookworm egg load (+ 0.67 g/dl vs. - 0.67 g/dl) and was also of significant benefit to the 38% of children with anaemia and light hookworm egg load (+ 0.07 g/dl vs. - 0.21 g/dl). It was of no significant benefit to children who were not anaemic. This study suggests that single-dose anthelminthic treatment distributed in schools in this area achieves haematological benefits in nearly half of children infected with S. haematobium and geohelminths (37% of total population).