Higher atrophy rate of entorhinal cortex than hippocampus in AD
Higher atrophy rate of entorhinal cortex than hippocampus in AD
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DOI：
10.1212/01.wnl.0000106462.72282.90
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发表时间：
2004-02-10
期刊：
影响因子：
9.9
通讯作者：
Weiner, MW
中科院分区：
文献类型：
--
作者：
Du, AT;Schuff, N;Weiner, MW
目的：确定阿尔茨海默病（AD）患者的内嗅皮质（ERC）萎缩率是否高于海马，确定海马萎缩率与记忆障碍之间的关系，并比较ERC和海马的萎缩率在区分AD患者和认知正常（CN）对照中的作用。方法：20例AD患者和25例CN患者相隔约1.9年进行两次MRI扫描和临床评估。在体积t1加权MR图像上，人工测量ERC体积，半自动测量海马体积。结果：AD组ERC萎缩率（7.1+/-3.2%/年）高于AD组(p
Objectives: To determine if atrophy rates were higher for entorhinal cortex (ERC) than for hippocampus in Alzheimer disease (AD), to determine the relationship between hippocampal atrophy rate and memory impairment, and to compare atrophy rates of ERC and hippocampus in differentiating between patients with AD and cognitively normal (CN) controls. Methods: Twenty patients with AD and 25 CN subjects had MRI scans and clinical evaluations twice approximately 1.9 years apart. ERC volumes were measured manually and hippocampal volumes were measured semiautomatically on volumetric T1-weighted MR images. Results: In AD, the atrophy rate of ERC (7.1+/-3.2%/year) was higher (p