Unveiling Organocatalysts Action – Investigating Immobilized Catalysts at Steady‐State Operation via Lab‐on‐a‐Chip Technology
Unveiling Organocatalysts Action – Investigating Immobilized Catalysts at Steady‐State Operation via Lab‐on‐a‐Chip Technology
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DOI：
10.1002/cctc.202101148
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发表时间：
2021-09
期刊：
影响因子：
4.5
通讯作者：
Hannes Westphal;Rico Warias;H. Becker;Matthias Spanka;D. Ragno;R. Gläser;C. Schneider;A. Massi;D. Belder
中科院分区：
文献类型：
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作者：
Hannes Westphal;Rico Warias;H. Becker;Matthias Spanka;D. Ragno;R. Gläser;C. Schneider;A. Massi;D. Belder
本文报道了一种小规模研究立体选择性催化反应的新方法。为此，将微型化学反应器和手性色谱柱集成在与质谱联用的单个微流体芯片上。通过在真正的连续流操作中使用自动化注射策略运行集成反应器，可以在很长的时间范围内观察催化过程及其立体选择性，样品、溶剂和催化材料的消耗量非常小。
This paper reports a new method for studying stereoselective catalyzed reactions at a small scale. For this purpose, a micro‐sized chemical reactor and a chiral chromatographic column were integrated on a single microfluidic chip hyphenated to mass spectrometry. By running the integrated reactor in truly continuous‐flow operation with an automated injection strategy, catalytic processes and their stereoselectivity can be observed over an extended range of time with significantly small consumption of samples, solvents, and catalytic material.