SEGMENTAL UTERINE HORN REPLACEMENT IN THE RAT USING A BIODEGRADABLE MICROPOROUS SYNTHETIC TUBE
SEGMENTAL UTERINE HORN REPLACEMENT IN THE RAT USING A BIODEGRADABLE MICROPOROUS SYNTHETIC TUBE
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DOI：
10.1111/j.1525-1594.1986.tb02607.x
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发表时间：
1986-12-01
影响因子：
2.4
通讯作者：
MOLENAAR, I
中科院分区：
文献类型：
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作者：
JONKMAN, MF;KAUER, FM;MOLENAAR, I
为了研究可生物降解的微孔合成管用于输卵管置换的可能性，研究了大鼠子宫角中的聚醚聚氨酯/聚L-丙交酯（PU/PLLA）移植物，并将其通畅性和愈合特征与不可生物降解的聚四氟乙烯（PTFE; Teflon）移植物以及重新闭合的子宫角进行了比较。关于愈合特征，PU/PLLA移植物上级于PTFE移植物，如子宫内膜再生和广泛的移植物周围组织长入所示。然而，PU/PLLA和PTFE移植物的移植物/子宫内膜异位症被粘膜褶皱堵塞，所有粘膜褶皱均重新闭合，对照实验中的子宫角保持开放。总之，尽管生物可降解微孔PU/PLLA子宫角移植物比PTFE移植物具有更好的愈合特性，但它们容易在移植物/子宫连接处阻塞。输卵管手术中使用可生物降解微孔人工输卵管的可行性可能与使用黏连剂和/或夹板有关。
To investigate the possible use of a biodegradable microporous synthetic tube for fallopian tube replacement, polyetherurethane/poly‐L‐lactide (PU/PLLA) grafts in the uterine horn of the rat were studied and their patency and healing characteristics compared with those of nonbiodegradable polytetrafluoroethylene (PTFE; Teflon) grafts as well as with those of reanastomosed uterine horns. Regarding the healing characteristics, the PU/PLLA grafts were superior to the PTFE graft, as was indicated by the regeneration of endometrium and the extensive perigraft tissue ingrowth. However, the graft/uterine anastomoses of the PU/PLLA and PTFE grafts became obstructed by a plug of mucosal folds, all reanastomosed, uterine horns in the control experiments remaining open. In conclusion, although biodegradable microporous PU/PLLA uterine horn grafts have better healing characteristics than PTFE grafts, they easily obstruct at the graft/uterine junction. Mucosal suturing and/or the use of splints may contribute to the feasibility of biodegradable microporous artificial fallopian tubes in tubal surgery.