Visual motion integration in schizophrenia patients, their first-degree relatives, and patients with bipolar disorder
Visual motion integration in schizophrenia patients, their first-degree relatives, and patients with bipolar disorder
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DOI：
10.1016/j.schres.2004.04.002
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发表时间：
2005-05-01
影响因子：
4.5
通讯作者：
Holzman, PS
中科院分区：
文献类型：
--
作者：
Chen, Y;Bidwell, LC;Holzman, PS
许多精神分裂症患者表现出对相干运动的退化检测。这种视觉缺陷可能（1）是患有特定精神分裂症精神病的结果，（2）是患有严重疾病的非特异性影响（即，“全身性缺陷”），或（3）反映视觉运动处理系统的特性，这些特性在精神分裂症倾向的病理生理学中起先行的、可能的因果作用。为了区分这些可能性，我们测量了29名精神分裂症患者，20名精神分裂症患者的一级亲属，19名双相情感障碍患者和33名正常对照者检测相干运动方向的准确性。这项任务需要从随机的随机点图案的动态信号的集成，以辨别他们的运动方向。精神分裂症患者，作为一个群体，表现出显着升高的阈值检测连贯运动的方向，但精神分裂症患者和双相情感障碍患者的亲属在这项任务上没有不同于正常对照组。结果表明，视觉运动整合，通常介导的运动敏感的大脑区域，如中颞区，是受损的患者有临床表现的精神分裂症精神病，但完整的患者与非精神分裂症精神病（双相情感障碍）和精神分裂症患者的亲属。我们的研究结果表明，整合运动信号的缺陷，而具体的精神分裂症，似乎不是一个共同的家族特征。(C)2004 Elsevier B.V.保留所有权利。
Many schizophrenia patients show degraded detection of coherent motion. This visual deficit may (1) be a consequence of having a specifically schizophrenic psychosis, (2) be a non-specific effect of suffering from a severe illness (i.e., "generalized deficit"), or (3) reflect properties of the visual motion processing system that play an antecedent, possibly causal role in the pathophysiology of a disposition to schizophrenia. To distinguish among these possibilities, we measured the accuracy of detecting the direction of coherent motion in 29 schizophrenia patients, 20 first-degree relatives of schizophrenia patients, 19 patients with bipolar disorder and 33 normal controls. The task requires the integration of dynamic signals from stochastic random dot patterns in order to discern the direction of their motion. Schizophrenia patients, as a group, showed significantly elevated thresholds for detecting the direction of coherent motion, but relatives of schizophrenia patients and patients with bipolar disorder did not differ from normal controls on this task. The results indicate that visual motion integration, normally mediated in motion-sensitive brain areas such as the Middle Temporal Area, is impaired in patients with a clinically manifest schizophrenic psychosis, but is intact in patients with a non-schizophrenic psychosis (bipolar disorder) and in the relatives of schizophrenia patients. Our findings suggest that deficiencies in integrating motion signals, while specific for schizophrenia, do not seem to be a co-familial trait. (C) 2004 Elsevier B.V. All rights reserved.