Non-adherence to anti-tuberculosis treatment and determinant factors among patients with tuberculosis in northwest Ethiopia.
Non-adherence to anti-tuberculosis treatment and determinant factors among patients with tuberculosis in northwest Ethiopia.
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DOI：
10.1371/journal.pone.0078791
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Zeleke BM
中科院分区：
文献类型：
--
作者：
Adane AA;Alene KA;Koye DN;Zeleke BM
不坚持抗结核治疗是提高结核病治愈率和进一步降低医疗费用的关键挑战之一。结核病患者坚持抗结核治疗的情况不佳是埃塞俄比亚的一个主要问题。因此，本研究评估了埃塞俄比亚西北部结核病患者不依从抗结核治疗的水平及其相关因素。2013年2月20日至3月30日，在北贡达尔区进行了一项基于机构的横断面调查，调查对象是接受抗结核治疗的结核病患者。数据由经过培训的数据收集员使用结构化和预先测试的问卷收集。将数据输入EPI INFO 3.5.3版，并使用社会科学统计软件包（SPSS）20版进行分析。多元logistic回归分析用于识别相关性和控制潜在的混杂变量。计算具有95%置信区间的比值比（OR），认为p值<0.05具有统计学显著性。共采访了280名肺结核患者，其中55.7%为男性，近四分之三（72.5%）为城市居民。调查前最后一个月和最后四天的总体不遵守率分别为10%和13.6%。如果患者有健忘，则不依从性较高（AOR 7.04，95% CI 1.40-35.13），处于化疗的继续期（AOR：6.95，95% CI 1.81-26.73），在访谈期间有结核病症状（AOR：4.29，95% CI 1.53-12.03），并与HIV合并感染（AOR：4.06，95% CI 1.70-9.70）。不坚持抗结核治疗的比例很高。健忘、处于化疗的继续阶段、在访谈期间出现结核病症状以及合并感染HIV与不坚持抗结核治疗显著相关。应特别注意对有症状的患者、结核病/艾滋病病毒合并感染的患者以及处于结核病治疗继续阶段的患者进行依从性咨询。
Non-adherence to anti tuberculosis treatment is one of the crucial challenges in improving tuberculosis cure-rates and reducing further healthcare costs. The poor adherence to anti-tuberculosis treatment among patients with tuberculosis is a major problem in Ethiopia. Hence, this study assessed level of non-adherence to anti-tuberculosis therapy and associated factors among patients with tuberculosis in northwest Ethiopia. An institution based cross-sectional survey was conducted among tuberculosis patients who were following anti-tuberculosis treatment in North Gondar zone from February 20 – March 30, 2013. Data were collected by trained data collectors using a structured and pre-tested questionnaire. Data were entered to EPI INFO version 3.5.3 and analyzed using statistical package for social sciences (SPSS) version 20. Multiple logistic regressions were fitted to identify associations and to control potential confounding variables. Odds ratio (OR) with 95% confidence interval was calculated and p-values<0.05 were considered statistically significant. A total of 280 tuberculosis patients were interviewed; 55.7% were males and nearly three quarters (72.5%) were urban dwellers. The overall non-adherence for the last one month and the last four days before the survey were 10% and 13.6% respectively. Non-adherence was high if the patients had forgetfulness (AOR 7.04, 95% CI 1.40–35.13), is on the continuation phase of chemotherapy (AOR: 6.95, 95% CI 1.81–26.73), had symptoms of tuberculosis during the interview (AOR: 4.29, 95% CI 1.53–12.03), and had co-infection with HIV (AOR: 4.06, 95% CI 1.70–9.70). Non-adherence to anti-tuberculosis treatment was high. Forgetfulness, being in the continuation phases of chemotherapy, having symptoms of tuberculosis during the interview, and co-infected with HIV were significantly associated with non-adherence to anti-tuberculosis therapy. Special attention on adherence counseling should be given to symptomatic patients, TB/HIV co-infected patients, and those in the continuation phase of the tuberculosis therapy.
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影响因子：
15.8
作者：
Shargie, Estifanos Biru;Lindtjorn, Bernt
通讯作者：
Lindtjorn, Bernt
影响因子：
3.7
作者：
Garrido Mda S;Penna ML;Perez-Porcuna TM;de Souza AB;Marreiro Lda S;Albuquerque BC;Martínez-Espinosa FE;Bührer-Sékula S
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Bührer-Sékula S
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1
作者：
Govender, S.;Mash, R.
通讯作者：
Mash, R.
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5.9
作者：
Sardar, Partha;Jha, Ayan;Bandyopadhyay, Dipanjan
通讯作者：
Bandyopadhyay, Dipanjan
影响因子：
4.5
作者：
Gebremariam MK;Bjune GA;Frich JC
通讯作者：
Frich JC