Sequences from Ancestral Single-Stranded DNA Viruses in Vertebrate Genomes: the Parvoviridae and Circoviridae Are More than 40 to 50 Million Years Old
Sequences from Ancestral Single-Stranded DNA Viruses in Vertebrate Genomes: the Parvoviridae and Circoviridae Are More than 40 to 50 Million Years Old
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DOI：
10.1128/jvi.01789-10
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发表时间：
2010-12-01
影响因子：
5.4
通讯作者：
Skalka, Anna Marie
中科院分区：
文献类型：
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作者：
Belyi, Vladimir A.;Levine, Arnold J.;Skalka, Anna Marie
分析脊椎动物基因组组装体中与任何已知的具有单链DNA基因组的病毒相关的内源序列。发现了许多与圆环病毒科和细小病毒科中的两个属（细小病毒和依赖病毒）相关的高置信度实例，并广泛分布于测试的49种脊椎动物中的31种。我们的分析表明，这两个病毒家族的年龄可能超过4000万至5000万年。这些病毒复制策略的共同特征可以解释整合的高发生率。
Vertebrate genomic assemblies were analyzed for endogenous sequences related to any known viruses with single-stranded DNA genomes. Numerous high-confidence examples related to the Circoviridae and two genera in the family Parvoviridae, the parvoviruses and dependoviruses, were found and were broadly distributed among 31 of the 49 vertebrate species tested. Our analyses indicate that the ages of both virus families may exceed 40 to 50 million years. Shared features of the replication strategies of these viruses may explain the high incidence of the integrations.