Role of vitamin K and Gla proteins in the pathophysiology of osteoporosis and vascular calcification.
Role of vitamin K and Gla proteins in the pathophysiology of osteoporosis and vascular calcification.
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DOI：
10.1097/00075197-200011000-00004
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发表时间：
2000-11-01
影响因子：
3.1
通讯作者：
Shearer, M J
中科院分区：
文献类型：
--
作者：
Shearer, M J
在已知或怀疑参与骨和血管生物学的蛋白质中，有几个维生素K依赖性或Gla蛋白家族的成员。本文综述了其中两个的作用：骨钙素和基质Gla蛋白。骨钙素代谢通过一种未知的机制与骨质疏松症的发病机制有关，该机制可能与维生素K状态欠佳有关，导致其羧化不足和推测的功能障碍。最近的研究已经调查了这一假设进行了讨论，是最近有前途的临床研究维生素K补充骨质疏松症。最近描述的基质Gla蛋白的功能是作为动脉和软骨钙化的有力抑制剂。在此期间所涵盖的审查有几个具有里程碑意义的研究，使用细胞系统，整个动物和遗传技术，巩固和扩展了我们的知识的作用，基质Gla蛋白在预防异位钙化。
Among the proteins known or suspected to be involved in bone and vascular biology are several members of the vitamin K-dependent or Gla protein family. This review focuses on the role of two of these: osteocalcin and matrix Gla protein. Osteocalcin metabolism has been implicated in the pathogenesis of osteoporosis through an unknown mechanism that may be linked to suboptimal vitamin K status resulting in its undercarboxylation and presumed dysfunction. Recent studies that have investigated this hypothesis are discussed, as are recent promising clinical studies of vitamin K supplementation in osteoporosis. A recently delineated function of matrix Gla protein is as a powerful inhibitor of calcification of arteries and cartilage. In the period covered by this review there have been several landmark studies using cell systems, whole animals and genetic techniques that have consolidated and extended our knowledge of the role of matrix Gla protein in the prevention of ectopic calcification.