SPLENIC STUDIES .1. SUSCEPTIBILITY TO INFECTION AFTER SPLENECTOMY PERFORMED IN INFANCY
SPLENIC STUDIES .1. SUSCEPTIBILITY TO INFECTION AFTER SPLENECTOMY PERFORMED IN INFANCY
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DOI：
10.1097/00000658-195208000-00006
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发表时间：
1952-01-01
影响因子：
9
通讯作者：
SHUMACKER, HB
中科院分区：
文献类型：
--
作者：
KING, H;SHUMACKER, HB
在印第安纳州大学医学中心进行的大约100例脾切除术中，有5例是在6个月以下的婴儿中进行的。本文特别关注的是这五例患者，尤其是他们术后感染的易感性。五名婴儿中有四名在手术后六周至三年内发展为脑膜炎或脑膜炎双球菌血症，其中一名死于感染。第五个孩子在脾切除术后出院几天后返回医院，出现了快速致命的发热性疾病，具有传染性。为了了解是否有人观察到脾切除术与随后的严重感染易感性之间的这种特殊联系，我们仔细回顾了有关脾切除术的文献。获得的相关信息很少。在许多报告中没有提到进行手术的年龄，只有极少数情况下说，脾切除术是在生命的前六个月进行的。此外，大多数报告不包括足够长的随访研究，以确定或排除随后的严重感染。然而，有一个有趣的例子，一个早产儿在妊娠35周时出生，14小时后接受了脾切除术。
AMONG APPROXIMIATELY 100 splenectomies performed at the Indiana University Medical Center, five have been carried out in infants under the age of six months. It is specifically with this group of five cases, and more particularly with their susceptibility to infection after operation, that this paper is concerned. Four of the five infants developed either meningitis or overwhelming meningococcemia in from six weeks to three years after operation and one of the four died of the infection. The fifth child was returned to the hospital a few days after discharge following splenectomy with a rapidly fatal febrile illness, suggestively infectious in nature.In an effort to learn whether this extraor-dinary association of splenectomy in in-fancy and subsequent susceptibility to severe infection had been observed by others, theliterature dealing with splenec-tomy was carefully reviewed. Little perti-nent information was obtained. The age at which the operation was performed is not mentioned in many reports and in only a very few instances is it stated that splenec-tomy was carried out during the first six months of life. Furthermore, most of the reports do not include sufficiently long follow-up studies to establish or rule out subsequent serious infection. One interesting account2 was found, however, of a prema-ture infant born at 35 weeks ofgestation and treated by splenectomy 14 hours after