How and why does the endoplasmic reticulum move?
How and why does the endoplasmic reticulum move?
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DOI：
10.1042/bst0370961
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发表时间：
2009-10-01
影响因子：
3.9
通讯作者：
Allan, Viki
中科院分区：
文献类型：
--
作者：
Bola, Becky;Allan, Viki
内质网是一种非常有活力的细胞器，不断地运动和重组。它具有许多关键作用，包括蛋白质合成、折叠和运输、钙稳态和脂质合成。当需要时，它可以在尺寸上膨胀，并且可以改变管状和层状区域之间的平衡。ER的分布和组织取决于与微管和肌动蛋白细胞骨架的运动和静态相互作用。在本文中，我们回顾了ER如何移动，并考虑为什么这种运动可能是重要的ER和细胞功能。
The ER (endoplasmic reticulum) is a fascinating organelle that is highly dynamic, undergoing constant movement and reorganization. it has many key roles, including protein synthesis, folding and trafficking, calcium homoeostasis and lipid synthesis. it can expand in size when needed, and the balance between tubular and lamellar regions can be altered. The distribution and organization of the ER depends on both motile and static interactions with microtubules and the actin cytoskeleton. In the present paper, we review how the ER moves, and consider why this movement may be important for ER and cellular function.