Practical Guidelines for Collection, Manipulation and Inactivation of SARS-CoV-2 and COVID-19 Clinical Specimens.
Practical Guidelines for Collection, Manipulation and Inactivation of SARS-CoV-2 and COVID-19 Clinical Specimens.
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DOI：
10.1002/cpcy.77
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发表时间：
2020-06-01
影响因子：
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通讯作者：
Stitt-Fischer, Molly S
中科院分区：
文献类型：
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作者：
Bain, William;Lee, Janet S;Stitt-Fischer, Molly S
SARS-CoV-2是一种新型冠状病毒，可导致急性呼吸道疾病-2019冠状病毒病（COVID-19）-导致全球健康危机。目前，还没有药物或疗法来控制病毒传播或减轻疾病。因此，医生和科学家感染的风险很高，如果要分离或繁殖病毒，则需要在生物安全3级（BSL-3）设施中进行工作。然而，灭活病毒可以在降低的生物安全水平下进行安全处理，使各种机构和调查人员都能获得样本。所有类型的机构都迫切需要概述疑似含有活性病毒的样本的安全收集、处理和灭活的指南。在这里，我们为希望使用COVID-19阳性或疑似阳性患者材料的医生和研究人员提供实用指南。© 2020 Wiley Periodicals LLC.基本方案1：安全采集和处理COVID-19和疑似COVID-19患者标本的实用指南基本方案2：灭活SARS-CoV-2。
SARS-CoV-2 is a novel coronavirus that causes the acute respiratory disease-Coronavirus disease 2019 (COVID-19)-which has led to a global health crisis. Currently, no prophylactics or therapies exist to control virus spread or mitigate the disease. Thus, the risk of infection for physicians and scientists is high, requiring work to be conducted in Biosafety Level-3 (BSL-3) facilities if virus will be isolated or propagated. However, inactivation of the virus can enable safe handling at a reduced biosafety level, making samples accessible to a diverse array of institutions and investigators. Institutions of all types have an immediate need for guidelines that outline safe collection, handling, and inactivation of samples suspected to contain active virus. Here we provide a practical guide for physicians and researchers wishing to work with materials from patients who are COVID-19 positive or suspected positive. © 2020 Wiley Periodicals LLC. Basic Protocol 1: Practical guidelines for the safe collection and handling of specimens collected from COVID-19 and suspected COVID-19 patients Basic Protocol 2: Inactivating SARS-CoV-2.