Reduced capacity to sustain positive emotion in major depression reflects diminished maintenance of fronto-striatal brain activation
Reduced capacity to sustain positive emotion in major depression reflects diminished maintenance of fronto-striatal brain activation
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DOI：
10.1073/pnas.0910651106
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发表时间：
2009-12-29
影响因子：
11.1
通讯作者：
Davidson, Richard J.
中科院分区：
文献类型：
--
作者：
Heller, Aaron S.;Johnstone, Tom;Davidson, Richard J.
快感缺乏症，即对先前有益的刺激失去快感或兴趣，是重度抑郁症的一个核心特征。虽然理论家们认为快感缺乏反映了体验快乐的能力下降，但关于快感缺乏是否由享乐能力下降引起的证据不一。另一种解释是，快感缺乏是由于无法长期保持积极的影响。使用积极的图像，我们使用情绪调节任务来测试抑郁症患者是否无法维持积极影响和奖励背后的神经回路的激活。与对照组相比，抑郁个体在上调积极情绪的同时，未能长期维持伏隔核的活动。这种能力的下降与自我报告的积极影响的个体差异有关。连通性分析进一步暗示了快感缺乏症的额纹状体网络。这些发现支持了一种假设，即抑郁症患者的快感缺乏症反映了参与积极影响和奖励的结构无法维持参与。
Anhedonia, the loss of pleasure or interest in previously rewarding stimuli, is a core feature of major depression. While theorists have argued that anhedonia reflects a reduced capacity to experience pleasure, evidence is mixed as to whether anhedonia is caused by a reduction in hedonic capacity. An alternative explanation is that anhedonia is due to the inability to sustain positive affect across time. Using positive images, we used an emotion regulation task to test whether individuals with depression are unable to sustain activation in neural circuits underlying positive affect and reward. While upregulating positive affect, depressed individuals failed to sustain nucleus accumbens activity over time compared with controls. This decreased capacity was related to individual differences in selfreported positive affect. Connectivity analyses further implicated the fronto-striatal network in anhedonia. These findings support the hypothesis that anhedonia in depressed patients reflects the inability to sustain engagement of structures involved in positive affect and reward.