Endothelin transfer and endothelin effects on water transfer in human fetal membranes.
Endothelin transfer and endothelin effects on water transfer in human fetal membranes.
复制标题
内皮素转移和内皮素对人胎膜水转移的影响。
DOI：
10.1097/00006250-199203000-00017
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发表时间：
1992
影响因子：
7.2
通讯作者：
Myatt,L
中科院分区：
文献类型：
--
作者：
Eis,AW;Mitchell,MD;Myatt,L
虽然内皮素-1是由人羊膜合成的，但其生理作用及其转移到肌层的催产作用尚不清楚。我们采用ususing chamber技术研究了内皮素-1自身的转移以及内皮素-1对氚水在人羊膜或羊膜/绒毛膜/蜕膜间转移的影响。在10 - 9 mol/L内皮素-1缺失或存在的情况下，3h2o通过羊膜/绒毛膜/蜕膜的渗透系数（平均±标准误差）在胎母方向分别为1.26±0.21和1.25±0.10× 10−4 cm/s (N= 6)，在母胎方向分别为0.90±0.07和0.98±0.15× 10−4 cm/s （N= 5）。与母体库中10−9 mol/L的内皮素-1在两个方向上均有相当的值。羊膜或羊膜/绒毛膜/蜕膜125 I内皮素-1在胎母方向的表观通透系数分别为3.34±0.79和2.43±0.68× 10−5 cm/s （N= 5）。然而，125i内皮素-1明显被胎膜捕获。内皮素-1似乎不影响水在人胎膜上的运动，只有一小部分内皮素-1本身在胎膜上转移。（妇产科杂志1992；79:411-5）
Although endothelin-1 is synthesized by human amnion, its physiologic role and its ability to be transferred to myometrium for oxytocic action remain unclear. We investigated the transfer of endothelin-1 itself and the effects of endothelin-1 on the transfer of tritiated water across human amnion or amnion/chorion/decidua in vitro with an Ussing chamber technique. Permeability coefficients (mean±standard error) for 3 H 2 O across amnion/chorion/decidua in the fetal to maternal direction were 1.26±0.21 and 1.25±0.10× 10− 4 cm/second (N= 6) and in the maternal to fetal direction 0.90±0.07 and 0.98±0.15× 10− 4 cm/second (N= 5) in the absence or presence, respectively, of 10− 9 mol/L endothelin-1 in the fetal reservoir. Comparable values were found in either direction with 10− 9 mol/L endothelin-1 in the maternal reservoir. Apparent permeability coefficients for 125 I endothelin-1 in the fetal to maternal direction were 3.34±0.79 and 2.43±0.68× 10− 5 cm/second (N= 5) for amnion or amnion/chorion/decidua. However, appreciable trapping of 125 I endothelin-1 by the fetal membranes was apparent. Endothelin-1 does not appear to affect water movement across the human fetal membranes, and only a small proportion of endothelin-1 itself is transferred across the membranes.(Obstet Gynecol 1992; 79: 411-5)