Pathogenesis of non-alcoholic fatty liver disease.
Pathogenesis of non-alcoholic fatty liver disease.
复制标题
非酒精性脂肪肝病的发病机理。
DOI：
10.1093/qjmed/hcp158
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发表时间：
2010-02
期刊：
影响因子：
--
通讯作者：
Newsome PN
中科院分区：
文献类型：
--
作者：
Dowman JK;Tomlinson JW;Newsome PN
非酒精性脂肪性肝病（NAFLD）代表了从肝细胞脂肪变性到脂肪性肝炎到纤维化和不可逆肝硬化的一系列疾病。NAFLD的患病率迅速上升，与肥胖和糖尿病的急剧上升并行，1，2并迅速成为西方国家肝病的最常见原因。事实上，NAFLD现在被认为是许多先前被标记为隐源性肝硬化的病例的病因。4在西方人群中，NAFLD患病率的估计值在20%至30%之间变化，5，6在病态肥胖个体中上升至90%。非酒精性脂肪性肝炎（NASH）是NAFLD的更严重和临床显著形式，不太常见，影响估计2-3%的一般人群，8和高达37%的病态肥胖。7特别值得关注的是，儿童和年轻人中NAFLD的患病率日益增加，这对未来的疾病负担具有重大影响。研究报告，一般儿科人群中NAFLD的患病率为3%，肥胖儿童的患病率上升至53%。9，10 NAFLD与2型糖尿病有很强的相关性，70%的2型糖尿病患者经超声筛查后出现脂肪变性，11因此现在认为NAFLD代表代谢综合征的肝脏表现。NAFLD发生于所有种族人群，尽管与西班牙裔和欧洲裔美国人相比，非裔美国人的患病率似乎较低。即使在控制肥胖和胰岛素抵抗（IR）后，这种差异仍然存在5，12，并且可能与脂质稳态的种族差异有关。5
Non-alcoholic fatty liver disease (NAFLD) represents a spectrum of disease ranging from hepatocellular steatosis through steatohepatitis to fibrosis and irreversible cirrhosis. The prevalence of NAFLD has risen rapidly in parallel with the dramatic rise in obesity and diabetes, 1, 2 and is rapidly becoming the most common cause of liver disease in Western countries. 3 Indeed, NAFLD is now recognized to be the aetiology in many cases previously labelled as cryptogenic cirrhosis. 4 In Western populations, estimates of NAFLD prevalence vary between 20 and 30%, 5, 6 rising up to 90% in morbidly obese individuals. 7 The more severe, and clinically significant form of NAFLD, non-alcoholic steatohepatitis (NASH) is less common, affecting an estimated 2–3% of the general population, 8 and up to 37% of the morbidly obese. 7 Of particular concern, and with significant implications for future disease burden, is the increasing prevalence of NAFLD in children and young adults. Studies have reported a 3% prevalence of NAFLD in the general paediatric population, rising to 53% in obese children. 9, 10 NAFLD has a strong association with type 2 diabetes, with steatosis present in 70% of type 2 diabetics screened with ultrasound, 11 and thus it is now recognized to represent the hepatic manifestation of the metabolic syndrome.NAFLD occurs in all ethnic groups although it appears to have a lower prevalence in African-Americans compared with Hispanic and European Americans. This difference remains even after controlling for obesity and insulin resistance (IR) 5, 12 and may be related to ethnic differences in lipid homeostasis. 5
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影响因子：
5.8
作者：
Andrews, RC;Rooyackers, O;Walker, BR
通讯作者：
Walker, BR
影响因子：
3.2
作者：
Day, CP
通讯作者：
Day, CP
影响因子：
29.4
作者：
Day, CP
通讯作者：
Day, CP
影响因子：
29.4
作者：
Aithal, Guruprasad P.;Thomas, James A.;Weeber, Jonathan
通讯作者：
Weeber, Jonathan
影响因子：
13.5
作者：
Browning, JD;Szczepaniak, LS;Hobbs, HH
通讯作者：
Hobbs, HH