Midbody: from cellular junk to regulator of cell polarity and cell fate.
Midbody: from cellular junk to regulator of cell polarity and cell fate.
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DOI：
10.1016/j.ceb.2015.04.010
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发表时间：
2015-08
影响因子：
7.5
通讯作者：
Prekeris R
中科院分区：
文献类型：
--
作者：
Dionne LK;Wang XJ;Prekeris R
在有丝分裂晚期，母细胞分裂形成一条分裂沟，留下两个子细胞，它们之间由一条细的细胞间桥连接。在卵裂沟的侵入过程中，纺锤体微管被压缩形成称为中间体（MB）的结构。MB位于细胞间桥内，其中解离位点有时发生在MB的一侧。由于这种单侧（不对称）脱落，只有一个子细胞可以继承有丝分裂后的MB。有趣的是，最近的研究已经将有丝分裂后MB确定为调节干细胞命运和增殖的新型信号平台。此外，MBs被认为在轴突生长和顶端腔形成过程中起极性提示的作用。因此，转录和MB遗传显然是一个高度调节的细胞事件，可以影响发育和各种其他细胞功能。在这篇综述中，我们讨论了最新的研究结果，有丝分裂后MB的功能，以及机械调节MB的遗传和积累。
At late mitosis, the mother cell divides by the formation of a cleavage furrow, leaving two daughter cells connected by a thin intercellular bridge. During ingression of the cleavage furrow, the central spindle microtubules are compacted to form the structure known as the midbody (MB). The MB is situated within the intercellular bridge, with the abscission site sometimes occurring on one side of the MB. As a result of this one-sided (asymmetric) abscission, only one daughter cell can inherit the post-mitotic MB. Interestingly, recent studies have identified post-mitotic MBs as novel signaling platforms regulating stem cell fate and proliferation. Additionally, MBs were proposed to serve a role of polarity cues during the neurite outgrowth and apical lumen formation. Thus, abscission and MB inheritance is clearly a highly regulated cellular event that can affect development and various other cellular functions. In this review we discuss the latest findings regarding post-mitotic MB functions, as well as the machinery regulating MB inheritance and accumulation.