PREVALENCE AND RELATIVE RISK OF ROTAVIRUS GASTROENTERITIS IN CHILDREN UNDER FIVE YEARS IN NIGERIA: A SYSTEMATIC REVIEW AND META-ANALYSIS
PREVALENCE AND RELATIVE RISK OF ROTAVIRUS GASTROENTERITIS IN CHILDREN UNDER FIVE YEARS IN NIGERIA: A SYSTEMATIC REVIEW AND META-ANALYSIS
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DOI：
10.1080/20477724.2022.2043223
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发表时间：
2022-03-07
影响因子：
3.4
通讯作者：
Chigor，Vincent
中科院分区：
文献类型：
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作者：
Digwo，Daniel;Chidebelu，Paul;Chigor，Vincent
轮状病毒是造成大多数5岁以下儿童胃肠炎和死亡的原因，特别是在发展中国家，包括尼日利亚。然而，关于轮状病毒流行率的全国估计数据有限。本系统综述和荟萃分析旨在确定尼日利亚5岁以下儿童轮状病毒感染的合并患病率及其相对风险。对1982年至2021年期间从“PubMed”，“Science Direct”，“Google Scholar”和“African Journal Online”，“Web of Science”，“Springer”，“Wiley”获得的合格发表研究进行了系统综述。合并患病率、相对危险度和区域亚组分析采用随机效应模型计算，置信区间为95%。本综述共处理了62项选定的研究，包括15项病例对照研究，来自18，849名儿童的汇总人群。尼日利亚全国5岁以下儿童轮状病毒合并患病率为23%（CI 95%; 19-27）。区域亚组分析显示，南部地区的患病率为27%（CI 95%; 21-32），而北方地区的患病率为20%（CI 95%; 16-25%），尽管差异不显著（P= 0.527）。轮状病毒与大多数急性胃肠炎病例有关，相对危险度为5.7（95%CI：2.9-11.2）。尼日利亚儿童轮状病毒感染的高患病率和相对风险表明轮状病毒是尼日利亚急性胃肠炎的重要原因。因此，需要进一步监测，特别是在社区一级，同时将轮状病毒疫苗纳入国家免疫规划。
Rotavirus is responsible for most cases of gastroenteritis and mortality in children below 5 years of age, especially in developing countries, including Nigeria. Nonetheless, there is limited data on the nationwide estimate for the prevalence of rotavirus. This systematic review and meta-analysis sought to determine the pooled prevalence of rotavirus infections and its relative risk among children below 5 years of age in Nigeria. Eligible published studies between 1982 and 2021 were accessed from ‘PubMed’, ‘Science Direct’, ‘Google Scholar’ and ‘African Journal Online’, ‘Web of Science’, ‘Springer’, ‘Wiley’ were systematically reviewed. The pooled prevalence, relative risk and regional subgroup analyses were calculated using the random effects model at 95% confidence interval (CI). A total of 62 selected studies, including 15 studies case-control studies, were processed in this review from a pooled population of 18,849 children. The nationwide pooled prevalence of rotavirus among children below 5 years of age in Nigeria was 23% (CI 95%; 19–27). Regional subgroup analysis showed that the Southern region had a prevalence of 27% (CI 95%; 21–32) while the Northern region had a 20% (CI 95%; 16–25%) prevalence, although the difference was not significant (P= 0.527). Rotavirus was implicated in most cases of acute gastroenteritis with a relative risk of 5.7 (95% CI: 2.9–11.2). The high prevalence and relative risk of rotavirus infections among children in Nigeria shows that rotavirus is an important cause of acute gastroenteritis in Nigeria. Thus, there is a need for further surveillance, especially at community levels together with the introduction of rotavirus vaccines into the national immunization program.