Apoptosis - an Ubiquitous T cell Immunomodulator.
Apoptosis - an Ubiquitous T cell Immunomodulator.
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DOI：
10.4172/2155-9899.s3-002
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发表时间：
2011-12-10
期刊：
影响因子：
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通讯作者：
Mehrotra S
中科院分区：
文献类型：
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作者：
Murali AK;Mehrotra S
细胞凋亡是一种自然过程，不再需要的细胞可以以高度调节和控制的方式被消除。细胞凋亡在维持哺乳动物免疫系统中是重要的，并且在免疫应答、阳性和阴性T细胞选择以及靶细胞的细胞毒性死亡中起重要作用。当细胞凋亡途径受损或未受到严格调控时，自身免疫性疾病、炎性疾病、病毒和细菌感染以及癌症随之而来。这些疾病与抗细胞凋亡因子和促细胞凋亡因子的失衡有关。此外，针对这些疾病的当前疗法集中于调节凋亡性死亡途径以调节免疫应答。在这篇综述中，我们将重点介绍T细胞活化和凋亡的过程中的自身免疫反应，在响应肿瘤的进展，以及在响应细菌和病毒感染。
Apoptosis is a natural process where cells that are no longer required can be eliminated in a highly regulated, controlled manner. Apoptosis is important in maintaining the mammalian immune system and plays a significant role in immune response, positive and negative T cell selection, and cytotoxic death of target cells. When the apoptotic pathways are impaired or are not tightly regulated, autoimmune diseases, inflammatory diseases, viral and bacterial infections and cancers ensue. An imbalance in the anti-apoptotic and pro-apoptotic factors has been implicated in these diseases. Moreover, current therapies directed towards these diseases focus on the modulation of the apoptotic death pathways to regulate the immune response. In this review, we will focus on the process of T cell activation and apoptosis in autoimmune reactions, in response to tumor progression as well as in response to bacterial and viral infections.