The effect of systemic antimicrobial therapy on plaque and gingivitis in dogs.
The effect of systemic antimicrobial therapy on plaque and gingivitis in dogs.
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全身抗菌治疗对狗牙菌斑和牙龈炎的影响。
DOI：
10.1111/j.1600-0765.1979.tb00219.x
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发表时间：
1979
影响因子：
3.5
通讯作者：
R. Parodi
中科院分区：
文献类型：
--
作者：
M. Listgarten;J. Lindhe;R. Parodi
将6只不同程度牙龈炎的狗分为3组，每组2只狗。一对狗接受四环素HCI 250 mg， 2次/天，持续4周。对照组在实验4周内不给药。结果表明，随着牙龈炎症程度的增加，牙周菌群中球形细胞和直杆细胞的比例降低，螺旋体和活动菌的比例明显降低。在消灭螺旋体方面，甲硝唑似乎比四环素更有效。抗菌药物治疗倾向于减少浸润结缔组织的大小和炎症细胞占据的连接上皮的比例，但不能完全消除炎症反应。在最初的检查中，约60%的白细胞在连接上皮中由嗜中性粒细胞组成。在期末检查时，由中性粒细胞组成的白细胞体积不到30%。从结果来看，尚不清楚临床和组织学参数的改善是由于某些生物体的特异性抑制还是总体抑制。牙周菌群体积的非特异性减少。
Six dogs with varying degrees of gingivitis wer divided into 3 groups of 2 dogs each. One pair of dogs received tetracycline HCI 250 mg, 2 times/day, for 4 weeks. The controls reveived no medication during the experimental period of 4 weeks. The results showed a decrease in the proportions of coccoid cells and straight rods in the periodontal flora with increasing gingival inflammation, while the proportions of spirochetes and motile bacteria were markedly reduced. Metronidazole appeared to be somewhat more effective in eliminating spirochetes than tetracycline. Treatment with the antimicropbial drugs tended to derease the size of th infiltrated connective tissue as well as the proportion of junctional epithelium occupied by inflammatory cells, but did not succeed in eliminating the inflammatory reaction entirely. At the initial examination around 60% of the leukocyte volume in junctional epthelium consisted of neutrophilic granulocytes. At the final examination less than 30 % of the leukocyte volume consisted of neutrophis. It was not clear from the results if the improvement in the clinical and histological parameters was due to the specific suppression of ertain organisms or to an overall. non-specific reduction in volume of the periodontal flora.