Rapid and label-free urine test based on surface-enhanced Raman spectroscopy for the non-invasive detection of colorectal cancer at different stages
Rapid and label-free urine test based on surface-enhanced Raman spectroscopy for the non-invasive detection of colorectal cancer at different stages
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DOI：
10.1364/boe.406097
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发表时间：
2020-12-01
影响因子：
3.4
通讯作者：
Feng, Shangyuan
中科院分区：
文献类型：
--
作者：
Lin, Jinyong;Huang, Zongwei;Feng, Shangyuan
能够在杯子里小便并筛查结直肠癌（CRC）的概念对公众来说很有吸引力。本研究采用基于表面增强拉曼光谱（SERS）的简单无标记尿液检测来检测结直肠癌。在正常、I-II期和III-IV期CRC尿液中观察到显著的光谱差异。通过判别函数分析，训练模型对正常、I-II期和III-IV期CRC的诊断灵敏度分别为95.8%、80.9%和84.3%，表明尿SERS作为一种快速、便捷、无创的CRC分期检测方法具有广阔的应用前景。(C) 2020年美国光学学会根据OSA开放获取出版协议的条款
The concept of being able to urinate in a cup and screen for colorectal cancer (CRC) is fascinating to the public at large. Here, a simple and label-free urine test based on surface-enhanced Raman spectroscopy (SERS) was employed for CRC detection. Significant spectral differences among normal, stages I-II, and stages III-IV CRC urines were observed. Using discriminant function analysis, the diagnostic sensitivities of 95.8%, 80.9%, and 84.3% for classification of normal, stages I-II, and stages III-IV CRC were achieved in training model, indicating the great promise of urine SERS as a rapid, convenient and noninvasive method for CRC staging detection. (C) 2020 Optical Society of America under the terms of the OSA Open Access Publishing Agreement