Geometric and Compositional Appearance of Atheroma in an Angiographically Normal Carotid Artery in Patients with Atherosclerosis
Geometric and Compositional Appearance of Atheroma in an Angiographically Normal Carotid Artery in Patients with Atherosclerosis
复制标题
DOI：
10.3174/ajnr.a1793
复制
发表时间：
2010-02-01
影响因子：
3.5
通讯作者：
Yuan, C.
中科院分区：
文献类型：
--
作者：
Dong, L.;Underhill, H. R.;Yuan, C.
背景和目的：动脉重塑可使动脉粥样硬化性疾病无管腔狭窄。我们试图评估血管造影正常的颈动脉动脉粥样硬化的患病率和特征。材料与方法：对46条MRA狭窄率为0%的动脉进行3T颈动脉磁共振多对比成像评估。记录每条动脉的壁体积百分比（壁体积/[管腔体积+壁体积]x 100%）以及LRNC、钙化、IPH和纤维帽破裂的存在与不存在。此外，计算存在时每个斑块成分的相对大小（例如，LRNC百分比= LRNC体积/壁体积X 100%）。结果：0%狭窄动脉壁容积百分比平均值为43.0±6.9%，范围为31.6% ~ 60.1%。67.4%（31/46）的动脉存在LRNC， 65.2%（30/46）的动脉存在钙化，8.7%（4/46）的动脉存在IPH， 4.3%（2/46）的动脉存在纤维帽破裂。在有LRNC的动脉中（n = 31）， LRNC体积的平均百分比为8.8±7.3%，范围为1.0% ~ 31.5%。对于钙化（n = 30），平均百分比钙化体积为3.8 +/- 4.2%，范围为0.1%-17.4%。平均IPH体积百分比（n = 4）为2.7 +/- 1.7%，范围为0.5%-4.1%。结论：这些发现表明MRA狭窄可能低估了颈动脉粥样硬化的存在，它们表明需要改进准确识别颈动脉粥样硬化斑块严重程度的方法。
BACKGROUND AND PURPOSE: Arterial remodeling may enable atherosclerotic disease without luminal stenosis. We sought to assess the prevalence and characteristics of atherosclerosis in angiographically normal carotid arteries.MATERIALS AND METHODS: Forty-six arteries with 0% stenosis by MRA were evaluated with multicontrast carotid MR imaging at 3T. For each artery, the percentage wall volume (wall volume/[lumen volume + wall volume] x 100%) and the presence versus absence of an LRNC, calcification, IPH, and fibrous cap rupture were recorded. In addition, the relative size of each plaque component (eg, percentage LRNC = LRNC volume/wall volume X 100%), when present, was calculated.RESULTS: The mean of percentage wall volume in arteries with 0% stenosis was 43.0 +/- 6.9% with a range from 31.6% to 60.1%. An LRNC was present in 67.4% (31/46) of arteries, calcification was present in 65.2% (30/46), IPH was present in 8.7% (4/46), and fibrous cap rupture was present in 4.3% (2/46). In arteries with an LRNC (n = 31), the average percentage LRNC volume was 8.8 +/- 7.3% with a range from 1.0% to 31.5%. For calcification (n = 30), the mean percentage calcification volume was 3.8 +/- 4.2% with a range of 0.1%-17.4%. The mean percentage IPH volume (n = 4) was 2.7 +/- 1.7% with a range of 0.5%-4.1%,CONCLUSIONS: These findings indicate that stenosis by MRA may underestimate the presence of carotid atherosclerosis, and they demonstrate the need for improved methods for accurately identifying carotid atherosclerotic plaque severity.